Grennan D M, Sloane D, Behan A, Dick W C
Ann Rheum Dis. 1977 Feb;36(1):30-3. doi: 10.1136/ard.36.1.30.
The clinical significance of antinative DNA antibodies as measured by the Farr test was investigated in 10 patients with the articular features of rheumatoid arthritis. 5 of these patients also satisfied criteria for a diagnosis of systemic lupus erythematosus (SLE) and might be classified as rheumatoid/lupus overlap syndromes or as rheumatoids with systemic complications. None had evidence of renal disease and 3 of the 5 had Sjgøren's syndrome. The sixth patient had aggressive peripheral arthritis, alopecia, and Sjøgren's syndrome and developed anti-DNA antibodies after treatment with penicillamine. All of the 4 rheumatoid patients with no clinical features typical of SLE had some special disease feature. The first had subclinical liver disease and the other 3 had Sjøgren's syndrome in addition to localized vasculitic skin ulceration (2) and pulmonary fibrosis (1).
通过法尔氏试验检测抗天然DNA抗体的临床意义，在10例具有类风湿性关节炎关节特征的患者中进行了研究。其中5例患者还符合系统性红斑狼疮（SLE）的诊断标准，可能被归类为类风湿/狼疮重叠综合征或伴有全身并发症的类风湿患者。无一例有肾脏疾病的证据，5例中有3例患有干燥综合征。第六例患者有侵袭性外周关节炎、脱发和干燥综合征，在用青霉胺治疗后出现抗DNA抗体。所有4例无SLE典型临床特征的类风湿患者均有一些特殊的疾病特征。第一例有亚临床肝病，另外3例除局部血管炎性皮肤溃疡（2例）和肺纤维化（1例）外，还患有干燥综合征。
