Tuomilehto Henri, Peltonen Markku, Partinen Markku, Seppä Juha, Saaristo Timo, Korpi-Hyövälti Eeva, Oksa Heikki, Puolijoki Hannu, Saltevo Juha, Vanhala Mauno, Tuomilehto Jaakko
Department of Otorhinolaryngology, Kuopio University Hospital, and University of Kuopio, Finland.
Sleep Med. 2008 Mar;9(3):221-7. doi: 10.1016/j.sleep.2007.04.015. Epub 2007 Jul 20.
To examine the association between sleep duration with type 2 diabetes and abnormal glucose tolerance among middle-aged men and women in Finland.
The FIN-D2D survey is a population-based cross-sectional multicentre study in Finland, with 1336 men and 1434 women aged 45-74 participating in the survey during 2004 and 2005. A health examination including an oral glucose tolerance test and sleep questionnaire was performed for all participants.
There was an independent association between abnormal sleeping times and type 2 diabetes in middle-aged women. Even after adjustments for age, body mass index, sleep apnea probability, smoking, physical activity, and central nervous system-affecting medication, sleep duration of 6h or less or 8h or longer was independently associated with type 2 diabetes. There was no increase in the prevalence of diabetes in middle-aged men with abnormal sleeping times.
Short (< or = 6h) or long (> or = 8h) sleep duration is related to an increased risk of type 2 diabetes in middle-aged women but not in men.
探讨芬兰中年男性和女性的睡眠时间与2型糖尿病及糖耐量异常之间的关联。
芬兰糖尿病预防研究（FIN-D2D）是一项基于人群的横断面多中心研究，2004年至2005年期间，共有1336名男性和1434名年龄在45 - 74岁的女性参与了该研究。对所有参与者进行了包括口服葡萄糖耐量试验和睡眠问卷在内的健康检查。
中年女性的异常睡眠时间与2型糖尿病之间存在独立关联。即使在对年龄、体重指数、睡眠呼吸暂停概率、吸烟、体育活动和影响中枢神经系统的药物进行调整后，6小时及以下或8小时及以上的睡眠时间仍与2型糖尿病独立相关。睡眠时间异常的中年男性糖尿病患病率没有增加。
睡眠时间短（≤6小时）或长（≥8小时）与中年女性患2型糖尿病的风险增加有关，但与男性无关。
