弗瑞德白血病病毒外壳蛋白合成的宿主限制
Host restriction of Friend Leukemia virus coat protein synthesis.
作者信息
Ray U, Soeiro R, Fields B N
出版信息
J Virol. 1976 Apr;18(1):370-3. doi: 10.1128/JVI.18.1.370-373.1976.
Abstract
Fv-1 gene-mediated host restriction of Friend leukemia virus replication was investigated in terms of coat protein synthesis. By using the assay of pseudotype formation with vesicular stomatitis virus. it was shown that under restricting growth conditions the availablity of leukemia virus coat protein for pseudotype formation was decreased. These studies appear to eliminate a pure assembly defect as the mechanism of Fv-1 host restriction.
摘要
从衣壳蛋白合成方面对Fv-1基因介导的宿主对Friend白血病病毒复制的限制作用进行了研究。通过使用水疱性口炎病毒假型形成试验，结果表明在限制生长条件下，用于假型形成的白血病病毒衣壳蛋白的可用性降低。这些研究似乎排除了纯粹的装配缺陷作为Fv-1宿主限制机制的可能性。
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本文引用的文献
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J Natl Cancer Inst. 1970 Jul;45(1):163-9.
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Host restriction of friend leukemia virus; fate of input virion RNA.宿主对Friend白血病病毒的限制；输入病毒粒子RNA的命运
Cell. 1974 Aug;2(4):271-7. doi: 10.1016/0092-8674(74)90021-x.
3
Reciprocal inhibition of mouse leukemia virus infection by Fv-1 allele cell extracts.Fv-1等位基因细胞提取物对小鼠白血病病毒感染的相互抑制作用。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4241-5. doi: 10.1073/pnas.71.10.4241.
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Virology. 1974 Jan;57(1):271-8. doi: 10.1016/0042-6822(74)90127-5.
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J Virol. 1973 Sep;12(3):659-62. doi: 10.1128/JVI.12.3.659-662.1973.
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