Gupta A, Hasan M, Chander R, Kapoor N K
Interdisciplinary Brain Research Centre, J.N. Medical College, Aligarh Muslim University, India.
Gerontology. 1991;37(6):305-9. doi: 10.1159/000213277.
Alteration in lipid peroxidation products such as lipid peroxides, lipid hydroperoxides were studied in different regions of CNS of ageing rats (13, 26, 52, 78 and 104 weeks). The levels of lipid peroxide and lipid hydroperoxide were increased in various regions of brain and spinal cord. However, the activity of superoxide dismutase was decreased in cerebrum, hypothalamus, hippocampus, cerebellum, brain stem and spinal cord. The present communication demonstrates that the different parts of CNS at 13 and 26 weeks of age have lipid peroxidation products different from that of 104-week-old rats.
在衰老大鼠（13、26、52、78和104周龄）中枢神经系统的不同区域，对脂质过氧化产物如脂质过氧化物、氢过氧化脂质的变化进行了研究。脑和脊髓的各个区域中脂质过氧化物和氢过氧化脂质的水平均有所升高。然而，大脑、下丘脑、海马体、小脑、脑干和脊髓中超氧化物歧化酶的活性却降低了。本报告表明，13周龄和26周龄中枢神经系统的不同部位，其脂质过氧化产物与104周龄大鼠的不同。
