Santin Matteo, Morris Christopher, Standen Guy, Nicolais Luigi, Ambrosio Luigi
School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Lewes Road, Brighton BN2 4GJ, United Kingdom.
Biomacromolecules. 2007 Sep;8(9):2706-11. doi: 10.1021/bm0703362. Epub 2007 Jul 27.
The reconstruction of large bone defects in periodontal, maxillofacial, and orthopedic surgery relies on the implantation of biomaterials able to support the growth of new tissue. None of the materials currently available is able to combine all the properties required, which are (i) easy handling, (ii) biodegradation, (iii) low immunogenicity, and more importantly, (iv) induction of tissue regeneration. A new class of biodegradable biomaterials has been obtained by simple thermosetting of defatted soybean curd. The final material can be processed into films, porous scaffolds, and granules for different surgical needs. When incubated in physiological solutions the material shows water uptake of 80%, elongation at break of 0.9 mm/mm, and 25% (w/w) degradation in 7 days. Soybean-based biomaterial granules are shown to reduce the activity of the monocytes/macrophages and of the osteoclasts and to induce osteoblast differentiation in vitro, thus demonstrating a bone regeneration potential suitable for many clinical applications.
牙周、颌面及整形外科手术中大型骨缺损的修复依赖于能够支持新组织生长的生物材料植入。目前可用的材料均无法兼具所需的所有特性，这些特性包括：（i）易于操作；（ii）可生物降解；（iii）低免疫原性，更重要的是，（iv）诱导组织再生。通过对脱脂豆腐进行简单热固化，已获得一类新型可生物降解生物材料。最终材料可加工成薄膜、多孔支架和颗粒，以满足不同手术需求。该材料在生理溶液中孵育时，吸水率达80%，断裂伸长率为0.9mm/mm，7天内降解25%（w/w）。基于大豆的生物材料颗粒可降低单核细胞/巨噬细胞和破骨细胞的活性，并在体外诱导成骨细胞分化，从而证明其具有适用于多种临床应用的骨再生潜力。
