2,4-二羟基喹啉（DHQ）是铜绿假单胞菌和泰国伯克霍尔德菌产生的一种新鉴定出的代谢产物，其生物合成需要PqsA。
PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis.
作者信息
Lépine François, Dekimpe Valérie, Lesic Biliana, Milot Sylvain, Lesimple Alain, Mamer Orval A, Rahme Laurence G, Déziel Eric
机构信息
INRS-Institut Armand-Frappier, Laval H7V 1B7, Québec, Canada.
出版信息
Biol Chem. 2007 Aug;388(8):839-45. doi: 10.1515/BC.2007.100.
Abstract
A new metabolite, 2,4-dihydroxyquinoline (DHQ), was identified in cultures of the bacteria Pseudomonas aeruginosa and Burkholderia thailandensis. We found that the biosynthesis of DHQ correlates with the presence of a functional PqsA, which is a product of the pqsABCDE operon responsible for the synthesis of 4-hydroxy-2-alkylquinolines (HAQs) in P. aeruginosa. However, DHQ is not a degradation product or precursor of HAQs. This finding sheds some light on the poorly understood biosynthesis pathway of HAQs, which includes important communication signals regulating the expression of virulence factors.
摘要
在铜绿假单胞菌和泰国伯克霍尔德氏菌的培养物中鉴定出一种新的代谢物2,4-二羟基喹啉（DHQ）。我们发现DHQ的生物合成与功能性PqsA的存在相关，PqsA是铜绿假单胞菌中负责合成4-羟基-2-烷基喹啉（HAQs）的pqsABCDE操纵子的产物。然而，DHQ不是HAQs的降解产物或前体。这一发现为人们了解甚少的HAQs生物合成途径提供了一些线索，HAQs生物合成途径包括调节毒力因子表达的重要通讯信号。
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