Pichon Christophe, Felden Brice
INSERM U835, Upres JE2311, Biochimie Pharmaceutique, Université de Rennes 1, Rennes, France.
FEMS Microbiol Rev. 2007 Sep;31(5):614-25. doi: 10.1111/j.1574-6976.2007.00079.x. Epub 2007 Jul 26.
Small regulatory RNAs have been identified in a wide range of organisms, where they modify mRNA stability, translation or protein function. Small RNA regulators (sRNAs) either pair with mRNA targets or modify protein activities. Here we discuss current knowledge of the various proteins that interact with RNA regulators and review the physiologic implications of sRNA-protein complexes in DNA, RNA and protein metabolism, as well as in RNA and protein quality control in prokaryotes. Proteins that interact with the sRNAs can possess catalytic activity, induce conformational changes of the sRNA, or be sequestered by the sRNA to prevent the action of the protein.
在多种生物体中都已鉴定出小型调节RNA，它们可改变mRNA的稳定性、翻译过程或蛋白质功能。小型RNA调节因子（sRNA）要么与mRNA靶标配对，要么改变蛋白质活性。本文我们将讨论与RNA调节因子相互作用的各种蛋白质的现有知识，并综述sRNA-蛋白质复合物在原核生物的DNA、RNA和蛋白质代谢以及RNA和蛋白质质量控制中的生理意义。与sRNA相互作用的蛋白质可能具有催化活性，可诱导sRNA的构象变化，或者被sRNA隔离以阻止该蛋白质发挥作用。
