Guzman-Sanchez Daniela A, Ishiuji Yozo, Patel Tejesh, Fountain Julie, Chan Yiong Huak, Yosipovitch Gil
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
J Am Acad Dermatol. 2007 Nov;57(5):800-5. doi: 10.1016/j.jaad.2007.06.009. Epub 2007 Jul 20.
Although patients with rosacea often complain of increased skin sensitivity, there has been no quantitative sensory testing of this phenomenon. Furthermore, cutaneous blood flow in these patients has not been assessed using state-of-the-art laser Doppler imaging (LDI).
To assess heat pain thresholds and skin blood flow using quantitative thermal sensory testing and LDI in patients with untreated rosacea.
Of the total 24 subjects enrolled, 8 had papulopustular rosacea (PPR), 8 had erythematotelangiectatic rosacea (ETR) and 8 were control subjects. Subjective burning perception, heat pain threshold, skin blood flow, and skin temperature was assessed in all subjects. In the ETR and PPR groups, two areas were compared: affected and nonaffected.
Heat pain thresholds of areas affected by rosacea were lower than those of nonaffected areas. In addition, subjective burning perception was increased in rosacea patients when compared with control subjects. Although PPR-affected skin had elevated skin blood flow when compared with nonaffected skin, this was not significant for ETR-affected skin.
The small number of subjects enrolled was the main limitation.
This study showed enhanced sensitivity to noxious heat stimuli in rosacea-affected skin, which was more prominent in the PPR group.
尽管酒渣鼻患者常抱怨皮肤敏感性增加，但尚未对这一现象进行定量感觉测试。此外，这些患者的皮肤血流尚未使用最先进的激光多普勒成像（LDI）进行评估。
使用定量热感觉测试和LDI评估未经治疗的酒渣鼻患者的热痛阈值和皮肤血流。
在总共纳入的24名受试者中，8名患有丘疹脓疱型酒渣鼻（PPR），8名患有红斑毛细血管扩张型酒渣鼻（ETR），8名作为对照受试者。对所有受试者评估主观灼痛感觉、热痛阈值、皮肤血流和皮肤温度。在ETR组和PPR组中，比较两个区域：受累区域和未受累区域。
酒渣鼻受累区域的热痛阈值低于未受累区域。此外，与对照受试者相比，酒渣鼻患者的主观灼痛感觉增强。尽管与未受累皮肤相比，PPR受累皮肤的皮肤血流增加，但ETR受累皮肤的这种情况并不显著。
纳入的受试者数量较少是主要局限性。
本研究表明酒渣鼻受累皮肤对有害热刺激的敏感性增强，这在PPR组中更为突出。
