Schwenzer Nina F, Schraml Christina, Martirosian Petros, Boss Andreas, Claussen Claus D, Schick Fritz
Section on Experimental Radiology, Eberhard-Karls University, Tübingen, Germany.
NMR Biomed. 2008 Jul;21(6):598-605. doi: 10.1002/nbm.1231.
To investigate the feasibility of blood flow imaging in the parotid gland using the arterial spin labeling (ASL) technique for assessment of functional changes in the parotid gland after gustatory stimulation.
Anatomical and ASL imaging of the parotid gland was performed in eight healthy volunteers before and after gustatory stimulation over a period of 17 min. All measurements were carried out in a 1.5 T whole-body MR unit. ASL and data recording were performed with an adapted FAIR TrueFISP (flow-sensitive alternating inversion-recovery true fast imaging with steady precession) technique. Maps of estimated tissue blood inflow in both parotid glands were derived using a simplified model and the extended Bloch equations.
Delineation of the parotid glands was possible on FAIR TrueFISP images in all cases. In the 160 s period immediately after stimulation, a significant (P < 0.01) mean increase of 62% in the estimated parotid blood flow was observed. Estimated baseline blood flow before gustatory stimulation ranged from 226 to 500 mL/min/100 g (mean +/- SD 335 +/- 86). These rates increased in the 160 s immediately after stimulation to 404-772 mL/min/100 g (mean 542 +/- 108). In all volunteers, blood flow returned to near baseline values within the observation period. No statistically significant difference between the right and left parotid was observed in baseline and peak blood flow.
ASL FAIR TrueFISP is feasible for functional characterization of the parotid glands. Assessment of changes in blood flow in the parotid gland could serve as a diagnostic tool in patients suffering from xerostomia.
探讨使用动脉自旋标记（ASL）技术进行腮腺血流成像以评估味觉刺激后腮腺功能变化的可行性。
在8名健康志愿者中，于味觉刺激前后17分钟内对腮腺进行解剖成像和ASL成像。所有测量均在1.5T全身MR设备上进行。采用改良的FAIR TrueFISP（流动敏感交替反转恢复稳态进动真快速成像）技术进行ASL和数据记录。使用简化模型和扩展的布洛赫方程得出双侧腮腺估计组织血流图。
在所有病例中，均可在FAIR TrueFISP图像上清晰显示腮腺。在刺激后的160秒内，观察到估计的腮腺血流平均显著增加（P < 0.01）62%。味觉刺激前估计的基线血流范围为226至500 mL/min/100g（平均±标准差335±86）。这些速率在刺激后的160秒内增加至404 - 772 mL/min/100g（平均542±108）。在所有志愿者中，血流在观察期内恢复至接近基线值。在基线和峰值血流方面，左右腮腺之间未观察到统计学上的显著差异。
ASL FAIR TrueFISP对于腮腺功能特征的表征是可行的。腮腺血流变化的评估可作为口干症患者的一种诊断工具。
