McEwan A, Cusick G, Holder D S
Department of Medical Physics and Bioengineering, UCL, London, UK.
Physiol Meas. 2007 Jul;28(7):S197-215. doi: 10.1088/0967-3334/28/7/S15. Epub 2007 Jun 26.
Multi-frequency electrical impedance tomography (MFEIT) was proposed over 10 years ago as a potential spectroscopic impedance imaging method. At least seven systems have been developed for imaging the lung, heart, breast and brain, yet none has yet achieved clinical acceptance. While the absolute impedance varies considerably between different tissues, the changes in the spectrum due to physiological changes are expected to be quite small, especially when measured through a volume. This places substantial requirements on the MFEIT instrumentation to maintain a flat system frequency response over a broad frequency range (dc-MHz). In this work, the EIT measurement problem is described from a multi-frequency perspective. Solutions to the common problems are considered from recent MFEIT systems, and the debate over four-terminal or two-terminal (multiple source) architecture is revisited. An analysis of the sources of MFEIT errors identifies the major sources of error as stray capacitance and common-mode voltages which lead to a load dependence in the frequency response of MFEIT systems. A system that employs active electrodes appears to be the most able to cope with these errors (Li et al 1996). A distributed system with digitization at the electrode is suggested as a next step in MFEIT system development.
多频电阻抗断层成像(MFEIT)早在十多年前就被提出,作为一种潜在的光谱阻抗成像方法。目前至少已经开发出七种用于肺部、心脏、乳房和脑部成像的系统,但尚未有任何一种获得临床认可。虽然不同组织之间的绝对阻抗差异很大,但由于生理变化引起的频谱变化预计会非常小,特别是通过一个体积进行测量时。这对MFEIT仪器提出了很高的要求,以便在很宽的频率范围(直流 - 兆赫兹)内保持平坦的系统频率响应。在这项工作中,从多频角度描述了电阻抗断层成像(EIT)测量问题。从最近的MFEIT系统中考虑了常见问题的解决方案,并重新审视了关于四端或两端(多源)架构的争论。对MFEIT误差源的分析确定主要误差源为杂散电容和共模电压,这会导致MFEIT系统频率响应中的负载依赖性。采用有源电极的系统似乎最能应对这些误差(Li等人,1996年)。建议在电极处进行数字化的分布式系统作为MFEIT系统开发的下一步。