肥胖的遗传因素
Genetic contributors to obesity.
作者信息
McPherson Ruth
机构信息
University of Ottawa Heart Institute, Ontario.
出版信息
Can J Cardiol. 2007 Aug;23 Suppl A(Suppl A):23A-27A. doi: 10.1016/s0828-282x(07)71002-4.
Abstract
Genetic and environmental factors interact to regulate body weight. Overall, the heritability of obesity is estimated at 40% to 70%. More than 244 genes have been found to strongly affect adiposity when overexpressed or deleted in mice. These genes can be considered in four broad categories: regulation of food intake by molecular signalling in the hypothalamus and hindbrain by signals originating in adipose tissue, gut and other organs; regulation of adipocyte differentiation and fat storage; regulation of spontaneous exercise activity; and effect on basal and postprandial thermogenesis. Rare variants in the coding sequences of major candidate genes account for an obese phenotype in 5% to 10% of individuals.
摘要
遗传因素和环境因素相互作用以调节体重。总体而言，肥胖的遗传度估计在40%至70%之间。在小鼠中过表达或缺失时，已发现超过244个基因会强烈影响肥胖程度。这些基因可大致分为四类：下丘脑和后脑通过源自脂肪组织、肠道及其他器官的信号进行分子信号传导来调节食物摄入；调节脂肪细胞分化和脂肪储存；调节自发运动活动；以及对基础和餐后产热的影响。主要候选基因编码序列中的罕见变异在5%至10%的个体中导致肥胖表型。
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