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本文引用的文献

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Care and treatment of HIV-infected children in Africa: issues and challenges at the district hospital level.非洲艾滋病毒感染儿童的护理与治疗：地区医院层面的问题与挑战
Pediatr Infect Dis J. 2007 Feb;26(2):163-73. doi: 10.1097/01.inf.0000253040.82669.22.
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Reducing the burden of HIV/AIDS in infants: the contribution of improved diagnostics.减轻婴儿感染艾滋病毒/艾滋病的负担：改进诊断方法的作用。
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HIV-1 viral load assays for resource-limited settings.针对资源有限环境的HIV-1病毒载量检测
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Optimized virus disruption improves detection of HIV-1 p24 in particles and uncovers a p24 reactivity in patients with undetectable HIV-1 RNA under long-term HAART.优化的病毒裂解可提高对颗粒中HIV-1 p24的检测，并揭示长期接受高效抗逆转录病毒治疗（HAART）的HIV-1 RNA检测不到的患者中的p24反应性。
J Med Virol. 2006 Aug;78(8):1003-10. doi: 10.1002/jmv.20655.
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Signal-boosted qualitative ultrasensitive p24 antigen assay for diagnosis of subtype C HIV-1 infection in infants under the age of 2 years.用于诊断2岁以下婴儿C型HIV-1感染的信号增强定性超灵敏p24抗原检测法
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Transfer and evaluation of an automated, low-cost real-time reverse transcription-PCR test for diagnosis and monitoring of human immunodeficiency virus type 1 infection in a West African resource-limited setting.在西非资源有限的环境中，用于诊断和监测1型人类免疫缺陷病毒感染的自动化、低成本实时逆转录聚合酶链反应检测方法的转移与评估。
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Multicenter evaluation of the NucliSens EasyQ HIV-1 v1.1 assay for the quantitative detection of HIV-1 RNA in plasma.用于定量检测血浆中HIV-1 RNA的NucliSens EasyQ HIV-1 v1.1检测法的多中心评估
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Pediatric human immunodeficiency virus screening in an African district hospital.非洲地区医院的儿科人类免疫缺陷病毒筛查
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9
Evaluation of an ultrasensitive p24 antigen assay as a potential alternative to human immunodeficiency virus type 1 RNA viral load assay in resource-limited settings.在资源有限的环境中，评估超灵敏p24抗原检测作为1型人类免疫缺陷病毒RNA病毒载量检测潜在替代方法的可行性。
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Introduction of routine HIV testing in prenatal care--Botswana, 2004.2004年博茨瓦纳在产前护理中引入常规艾滋病毒检测
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一种简化的p24检测法用于海地1型人类免疫缺陷病毒婴儿感染早期诊断的潜力

Potential of a simplified p24 assay for early diagnosis of infant human immunodeficiency virus type 1 infection in Haiti.

作者信息

George Erik, Beauharnais Carole Anne, Brignoli Emilio, Noel Francine, Bois Gyrlande, De Matteis Rouzier Patricia, Altenor Martine, Lauture Daniel, Hosty Marlène, Mehta Sapna, Wright Peter F, Pape Jean W

机构信息

Department of Medicine, Weill Medical College, Cornell University, New York, NY, USA.

出版信息

J Clin Microbiol. 2007 Oct;45(10):3416-8. doi: 10.1128/JCM.01314-07. Epub 2007 Aug 1.

DOI:10.1128/JCM.01314-07
PMID:17670933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2045325/
Abstract

With global efforts to scale up the prevention of mother-to-child transmission services and pediatric antiretroviral therapy, there is an urgent need to introduce a simple, low-cost infant human immunodeficiency virus test in the field. We postulated that the p24 antigen capture enzyme-linked immunosorbent assay could be simplified by eliminating signal amplification without compromising diagnostic accuracy.

摘要

随着全球加大力度扩大预防母婴传播服务和儿科抗逆转录病毒疗法的规模，在该领域迫切需要引入一种简单、低成本的婴儿人类免疫缺陷病毒检测方法。我们推测，通过消除信号放大而不影响诊断准确性，可以简化p24抗原捕获酶联免疫吸附测定法。