Turner G A, Paech M
Department of Anaesthesia, King Edward Memorial Hospital for Women, Perth, Western Australia.
Anaesth Intensive Care. 1991 Aug;19(3):365-8. doi: 10.1177/0310057X9101900309.
Seventy-five women undergoing elective day case gynaecological surgery were randomised into one of three groups to receive an oral formulation of midazolam IV solution 10 mg, temazepam 20 mg or placebo for premedication. The two treatment groups showed a significant reduction in anxiety score compared with placebo (P less than 0.002 and P less than 0.04 for placebo compared with temazepam and midazolam respectively). Similarly the treatment groups showed a significantly greater sedation score compared with placebo. Recovery as assessed by letter deletion and memory tests was no worse for the treatment groups than for placebo. Patient acceptance of the two treatment groups was significantly greater than that of placebo. There was no significant difference between treatment groups with respect to anxiolysis, sedation or recovery. As a day case premedicant, midazolam IV solution 10 mg orally was found to be as effective as temazepam 20 mg and superior to placebo, in terms of anxiolysis and sedation, but did not offer any clinical advantage over temazepam in this setting.
75名接受择期日间妇科手术的女性被随机分为三组，分别接受10毫克咪达唑仑静脉溶液口服制剂、20毫克替马西泮或安慰剂进行术前用药。与安慰剂相比，两个治疗组的焦虑评分均显著降低（安慰剂与替马西泮和咪达唑仑相比，P值分别小于0.002和小于0.04）。同样，与安慰剂相比，治疗组的镇静评分显著更高。通过字母删除和记忆测试评估的恢复情况，治疗组并不比安慰剂组差。两个治疗组的患者接受度显著高于安慰剂组。治疗组在抗焦虑、镇静或恢复方面没有显著差异。作为日间手术的术前用药，口服10毫克咪达唑仑静脉溶液在抗焦虑和镇静方面与20毫克替马西泮效果相当，且优于安慰剂，但在这种情况下与替马西泮相比没有任何临床优势。
