口蹄疫病毒O/Akesu/58株全基因组序列及其部分分子特征
The complete genome sequence of foot-and-mouth disease virus O/Akesu/58 strain and its some molecular characteristics.
作者信息
Li D, Liu Z-X, Bao H-F, Lu Z-J, Guo J-H, Cao Y-M, Li P-H, Bai X-W, Chen Y-L, Xie B-X, Cai X-P, Xie Q-G
机构信息
Key Laboratory of Animal Virology of Ministry of Agriculture, State Key Laboratory of Veterinary Etiologic Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
出版信息
Arch Virol. 2007;152(11):2079-85. doi: 10.1007/s00705-007-1041-y. Epub 2007 Aug 7.
The complete genome of O/Akesu/58 strain of foot-and-mouth disease virus (FMDV) was sequenced. The phylogenetic analysis revealed that it is not closely related to epidemic strains or previous strains compared with reference sequences (the identities of complete VP1 nucleotide sequences range from 77.5 to 84.0%). Its cell-receptor-binding site is a SGD (Ser-Gly-Asp) motif instead of RGD (Arg-Gly-Asp), and 43 bases were deleted in PKs region of the 5'UTR, although deletions were not found in other gene regions.
对口蹄疫病毒（FMDV）O/Akesu/58毒株的全基因组进行了测序。系统发育分析表明，与参考序列相比，它与流行毒株或先前毒株的亲缘关系并不密切（完整VP1核苷酸序列的同一性范围为77.5%至84.0%）。其细胞受体结合位点是一个SGD（丝氨酸-甘氨酸-天冬氨酸）基序而非RGD（精氨酸-甘氨酸-天冬氨酸），并且在5'UTR的PKs区域有43个碱基缺失，尽管在其他基因区域未发现缺失。
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