Nemes Attila, Gavallér Henriette, Csajbók Eva, Forster Tamás, Csanády Miklós
2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Medical and Pharmaceutical Centre, University of Szeged, Szeged, Hungary.
Int J Cardiovasc Imaging. 2008 Feb;24(2):165-71. doi: 10.1007/s10554-007-9248-2. Epub 2007 Aug 7.
Obesity may be associated with early vascular changes. The current study was designed to assess the relationship between obesity and aortic stiffness in two populations, one aged 18-40 years and one aged 41-64 years.
The study complied 121 subjects, all of them underwent a physical examination, transthoracic echocardiography and blood pressure measurement. Aortic stiffness index (beta) was evaluated from aortic diameter and blood pressure data.
beta was higher in obese subjects both in the young (4.26 +/- 1.57 vs. 6.88 +/- 5.96, P < 0.05) and old patient populations (7.13 +/- 4.99 vs. 14.89 +/- 14.64, P < 0.05). Systolic (SD) aortic diameters (in mm) were enlarged in obese young patients (25.7 +/- 2.8 vs. 27.1 +/- 2.5, P < 0.05) and obese old subjects (28.0 +/- 3.0 vs. 30.3 +/- 3.3, P < 0.05). Diastolic (DD) aortic diameter (in mm) showed similar tendency in youngs (22.8 +/- 2.9 vs. 24.9 +/- 2.5, P < 0.05) and old subjects (25.9 +/- 2.7 vs. 28.0 +/- 3.1, P < 0.05).
Aortic stiffness is higher in young obese patients and similar to older subjects without obesity. Both SD and DD are increasing with age, but subjects within similar age group have larger SD and DD suggesting early vascular remodelling in obesity.
肥胖可能与早期血管变化有关。本研究旨在评估18至40岁和41至64岁两个人群中肥胖与主动脉僵硬度之间的关系。
该研究纳入了121名受试者，他们均接受了体格检查、经胸超声心动图检查和血压测量。根据主动脉直径和血压数据评估主动脉僵硬度指数（β）。
在年轻（4.26±1.57对6.88±5.96，P<0.05）和老年患者人群中，肥胖受试者的β值均较高（7.13±4.99对14.89±14.64，P<0.05）。肥胖年轻患者的收缩期（SD）主动脉直径（单位：mm）增大（25.7±2.8对27.1±2.5，P<0.05），肥胖老年受试者也如此（28.0±3.0对30.3±3.3，P<0.05）。舒张期（DD）主动脉直径（单位：mm）在年轻人（22.8±2.9对24.9±2.5，P<0.05）和老年受试者中显示出类似趋势（25.9±2.7对28.0±3.1，P<0.05）。
年轻肥胖患者的主动脉僵硬度较高，与无肥胖的老年受试者相似。收缩期和舒张期主动脉直径均随年龄增加，但同一年龄组内的受试者收缩期和舒张期主动脉直径更大，提示肥胖患者存在早期血管重塑。
