Aström E, Friman G, Pilström L
Acta Pathol Microbiol Scand A. 1976 Mar;84(2):113-22. doi: 10.1111/j.1699-0463.1976.tb00080.x.
The effect on skeletal muscle of acute viral and mycoplasma infections in thirteen men of ages ranging between 20-42 years has been studied. Comparisons are made with eight healthy men in the age group 22-29 years who were confined to bed for periods of time of lengths similar to the confinement to bed of the patients. Muscle samples were taken from the thigh. Glyceraldehyde-3-phosphate (triosephosphate) dehydrogenase (TPD), lactate dehydrogenase (LDH), citrate synthetase (CS) and cytochrome oxidase (cytox) activities were measured and the ultrastructure of the muscle specimens was studied by electron microscopy. Immobilization of the healthy persons induced decreased activities of CS, but those of TPD, LDH and cytox remained unaffected. Return to normal life restored the CS activity. The activities of the four enzymes were lower in the patients than in the healthy subjects after immobilization. During normal life, the activities slowly rose to levels as those seen in the healthy subjects. In connection with the acute disease, focal ultrastructural changes within the muscle were found. The changes were similar to those reported to occur in other, more specific muscle diseases.
对13名年龄在20至42岁之间男性的急性病毒和支原体感染对骨骼肌的影响进行了研究。将其与8名年龄在22至29岁之间的健康男性进行比较，这些健康男性卧床的时间与患者卧床时间相似。从大腿采集肌肉样本。测量了甘油醛-3-磷酸（磷酸丙糖）脱氢酶（TPD）、乳酸脱氢酶（LDH）、柠檬酸合成酶（CS）和细胞色素氧化酶（cytox）的活性，并通过电子显微镜研究了肌肉标本的超微结构。健康人卧床导致CS活性降低，但TPD、LDH和cytox的活性未受影响。恢复正常生活后CS活性恢复。卧床后患者的这四种酶活性低于健康受试者。在正常生活期间，这些酶的活性缓慢上升至与健康受试者所见水平相同。与急性疾病相关，在肌肉内发现了局灶性超微结构变化。这些变化与其他更特殊的肌肉疾病中报道的变化相似。
