Gangell C L, Horak F, Patterson H J, Sly P D, Stick S M, Hall G L
School of Paediatrics and Child Health, Princess Margaret Hospital for Children, Perth, WA, Australia.
Eur Respir J. 2007 Nov;30(5):892-7. doi: 10.1183/09031936.00003407. Epub 2007 Aug 9.
Measurement of lung function is an important component of clinical management in cystic fibrosis (CF), but has been difficult in young children. The present study aimed to characterise the utility of the forced oscillation technique for measurement of lung function in preschool-aged children with CF in a routine clinical setting. Lung function was assessed in 56 young children (aged 2-7 yrs) with CF. Respiratory system resistance (R(rs)) and reactance (X(rs)) at 6, 8 and 10 Hz were measured and expressed as Z-scores. Children were classified as asymptomatic or symptomatic based on an administered respiratory questionnaire and physical examination at the time of testing. Between-test repeatability was assessed in 25 children. Measurement of lung function using the forced oscillation technique was feasible in the CF clinic. The children with CF, as a group, had Z-scores for R(rs) at 6 Hz (R(rs,6)) R(rs,8), R(rs,10), X(rs) at 6 Hz (X(rs,6)) and X(rs,8) that were significantly different from zero. Children with current symptoms showed significantly decreased X(rs) and increased R(rs,6) compared with asymptomatic children. Measurement of lung function using the forced oscillation technique is feasible in young children with cystic fibrosis in a clinical setting. The technique has the potential to improve knowledge concerning early cystic fibrosis lung disease.
肺功能测量是囊性纤维化（CF）临床管理的重要组成部分，但在幼儿中一直存在困难。本研究旨在描述强迫振荡技术在常规临床环境中测量学龄前CF儿童肺功能的效用。对56名患有CF的幼儿（年龄2至7岁）进行了肺功能评估。测量了6、8和10赫兹时的呼吸系统阻力（R(rs)）和电抗（X(rs)），并表示为Z分数。根据测试时进行的呼吸问卷和体格检查，将儿童分为无症状或有症状。对25名儿童进行了测试间重复性评估。在CF诊所中，使用强迫振荡技术测量肺功能是可行的。CF儿童作为一个群体，其6赫兹时的R(rs)（R(rs,6)）、R(rs,8)、R(rs,10)、6赫兹时的X(rs)（X(rs,6)）和X(rs,8)的Z分数与零有显著差异。与无症状儿童相比，当前有症状的儿童显示X(rs)显著降低，R(rs,6)升高。在临床环境中，使用强迫振荡技术测量患有囊性纤维化的幼儿的肺功能是可行的。该技术有可能提高对早期囊性纤维化肺病的认识。
