Tsai Wen-Chiuan, Chao You-Chen, Sheu Lai-Fa, Lin Yeh-Feng, Nieh Shin, Chen Ann, Yu Cheng-Pin, Jin Jong-Shiaw
Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
APMIS. 2007 Aug;115(8):929-38. doi: 10.1111/j.1600-0463.2007.apm_858.x.
The aim of this study was to test whether expression of EMMPRIN and fascin correlates with clinicopathologic parameters of pancreatobiliary adenocarcinoma. Immunohistochemical analysis of EMMPRIN and fascin was performed in 100 surgical specimens obtained from Chinese patients, including 18 well-differentiated, 62 moderately differentiated, and 20 poorly differentiated pancreatic and biliary adenocarcinomas. Neither EMMPRIN nor fascin was detectable in normal pancreatic and biliary glandular epithelia. However, EMMPRIN and fascin immunoreactivity was observed on the cell membrane and within the cytoplasm in pancreatobiliary adenocarcinomas. Higher immunostaining scores of EMMPRIN and fascin were strongly associated with advanced grades of pancreatobiliary adenocarcinomas (36.1 and 51.3 for grade I, 95.5 and 110.1 for grade II, and 133.7 and 165.8 for grade III). In addition, higher immunostaining scores of EMMPRIN and fascin were associated with advanced T stages (29.8 and 43.6 for T1, 86.3 and 93.2 for T2, 107.6 and 117.6 for T3, and 129.5 and 156.5 for T4). Higher EMMPRIN and fascin scores were associated with shorter survival times and more advanced M and N stages of pancreatiobiliary adenocarcinomas. A higher expression of EMMPRIN and fascin was found to correlate well with histologic grades and clinical stages of pancreatobiliary adenocarcinomas.
本研究的目的是检测EMMPRIN和fascin的表达是否与胰胆管腺癌的临床病理参数相关。对100例来自中国患者的手术标本进行了EMMPRIN和fascin的免疫组织化学分析，其中包括18例高分化、62例中分化和20例低分化的胰腺和胆管腺癌。在正常胰腺和胆管腺上皮中均未检测到EMMPRIN和fascin。然而，在胰胆管腺癌的细胞膜和细胞质内观察到了EMMPRIN和fascin免疫反应性。EMMPRIN和fascin的免疫染色评分越高，与胰胆管腺癌的高级别显著相关（I级分别为36.1和51.3，II级分别为95.5和110.1，III级分别为133.7和165.8）。此外，EMMPRIN和fascin的免疫染色评分越高，与T分期越晚相关（T1期分别为29.8和43.6，T2期分别为86.3和93.2，T3期分别为107.6和117.6，T4期分别为129.5和156.5）。较高的EMMPRIN和fascin评分与胰胆管腺癌的较短生存时间以及更晚的M和N分期相关。发现EMMPRIN和fascin的高表达与胰胆管腺癌的组织学分级和临床分期密切相关。
