Bufford Jeremy D, Gern James E
University of Wisconsin Hospital and Clinics, 600 Highland Avenue, K4/918, CSC Box 9988, Madison, WI 53792, USA.
Curr Allergy Asthma Rep. 2007 Sep;7(5):375-82. doi: 10.1007/s11882-007-0057-4.
Although pet exposure is known to trigger or worsen allergy symptoms and asthma in patients sensitized to pets, data from recent years has shown that pet exposure in early childhood may actually prevent the development of allergic sensitization and allergic diseases including allergic rhinitis, asthma, and atopic dermatitis. The concept of a protective pet effect remains controversial because these findings have not been duplicated in all studies. Moreover, some studies suggest that pet exposure promotes allergic disease. The protective pet effect may be influenced by multiple factors including type of pet; timing, duration, and intensity of exposure; and genetic factors. The mechanisms behind the protective pet effect remain under investigation but may include alterations in immune development, pet-specific tolerance, and exposure to innate immune stimuli.
虽然已知接触宠物会引发或加重对宠物敏感患者的过敏症状和哮喘,但近年来的数据表明,幼儿期接触宠物实际上可能预防过敏致敏及包括过敏性鼻炎、哮喘和特应性皮炎在内的过敏性疾病的发生。宠物的保护作用这一概念仍存在争议,因为这些研究结果并非在所有研究中都能得到重复验证。此外,一些研究表明接触宠物会促进过敏性疾病的发生。宠物的保护作用可能受多种因素影响,包括宠物类型、接触的时间、持续时间和强度以及遗传因素。宠物保护作用背后的机制仍在研究中,但可能包括免疫发育的改变、对宠物的特异性耐受以及接触先天性免疫刺激。