Sloan Erica K, Capitanio John P, Cole Steve W
Norman Cousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, UCLA School of Medicine, USA.
Brain Behav Immun. 2008 Jan;22(1):15-21. doi: 10.1016/j.bbi.2007.06.011. Epub 2007 Aug 13.
Lymphoid organs have long been known to harbor neural fibers from the sympathetic division of the autonomic nervous system, but recent studies suggest a surprising degree of plasticity in the density of innervation. This review summarizes data showing that behavioral stress can increase the density of catecholaminergic neural fibers within lymphoid organs of adult primates. Stress-induced neural densification is associated with increased expression of neurotrophic factors, and functional consequences include alterations in lymph node cytokine expression and increased replication of a lymphotropic virus. The finding that behavioral stress can tonically alter lymph node neural structure suggests that behavioral factors could exert long-term regulatory influences on the initiation, maintenance, and resolution of immune responses.
长期以来，人们一直认为淋巴器官中含有来自自主神经系统交感神经分支的神经纤维，但最近的研究表明，神经支配密度具有惊人的可塑性。这篇综述总结了相关数据，这些数据表明行为应激可增加成年灵长类动物淋巴器官内儿茶酚胺能神经纤维的密度。应激诱导的神经致密化与神经营养因子表达增加有关，其功能后果包括淋巴结细胞因子表达的改变以及嗜淋巴细胞病毒复制的增加。行为应激可持续改变淋巴结神经结构这一发现表明，行为因素可能对免疫反应的启动、维持和消退产生长期的调节影响。
