巴西亚马逊地区人类细小病毒B19的“压力锅”式进化

The "pressure pan" evolution of human erythrovirus B19 in the Amazon, Brazil.

作者信息

Barros de Freitas Ronaldo, Durigon Edison Luiz, Oliveira Darleise de Souza, Romano Camila Malta, Castro de Freitas Maria Rute, Linhares Alexandre da Costa, Melo Fernando Lucas, Walshkeller Lílian, Barbosa Maria Luisa, Huatuco Egma M Mayta, Holmes Edward C, Zanotto Paolo Marinho de A

机构信息

Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Belém, Brazil.

出版信息

Virology. 2007 Dec 20;369(2):281-7. doi: 10.1016/j.virol.2007.07.007. Epub 2007 Aug 15.

DOI:10.1016/j.virol.2007.07.007

PMID:17698162

Abstract

To understand the evolutionary dynamics of human parvovirus B19, we analyzed VP1 and VP2 gene sequences of B19 sampled from Belém (Amazon), the city of São Paulo, Brazil and globally. Our analysis revealed a strikingly different pattern of evolutionary change for those viral lineages introduced into Belém, which exhibited a higher rate of nonsynonymous substitutions compared to those viruses sampled from other locations. We propose that difference this is due to the high prevalence of B19 in Belém (up to 85%) compared to other locations (prevalences of approximately 50%), which imposes a more intense selection pressure. Hence, those B19 lineages introduced into Belém experienced an elevated rate of amino acid change, driven by positive selection, in order to generate serial re-infections in a small web of transmission, which can be thought of as an evolutionary "pressure pan".

摘要

为了解人细小病毒B19的进化动态，我们分析了从贝伦（亚马逊地区）、巴西圣保罗市以及全球范围内采集的B19的VP1和VP2基因序列。我们的分析揭示，引入贝伦的那些病毒谱系呈现出截然不同的进化变化模式，与从其他地点采集的病毒相比，它们的非同义替换率更高。我们认为，这种差异是由于贝伦地区B19的高流行率（高达85%），而其他地区的流行率约为50%，这施加了更强的选择压力。因此，引入贝伦的那些B19谱系在正向选择的驱动下，氨基酸变化率升高，以便在一个小的传播网络中产生连续的再感染，这可以被视为一个进化的“压力锅”。