巴西分离的一株红病毒 3 基因型近全长序列的系统进化分析。

Phylogenetic analysis of a near-full-length sequence of an erythrovirus genotype 3 strain isolated in Brazil.

机构信息

Institute of Biomedical Science, Department of Microbiology, University of Sao Paulo, Prof. Lineu Prestes 1374, Sao Paulo, Brazil.

出版信息

Arch Virol. 2009;154(10):1685-7. doi: 10.1007/s00705-009-0482-x. Epub 2009 Aug 22.

DOI:10.1007/s00705-009-0482-x

PMID:19701602

Abstract

Human parvovirus B19 is the only member of the genus Erythrovirus that causes human disease. Recent findings of several strains with considerable sequence divergence from B19 have suggested a new classification for parvovirus genotypes as 1 (B19), 2 (A-6 and LaLi) and 3 (V9). In their overall DNA sequence, the three genotypes differ by approximately 10%. Here, we report the isolation of a genotype-3-related strain named BR543 during a prospective study conducted in Sao Paulo, Brazil. Analysis of the nearly full-length genome sequence of BR543 indicates that this B19 variant sequence clusters with Gh2768, a strain from Ghana belonging to subtype 3b, and showed mostly synonymous substitutions.

摘要

人细小病毒 B19 是唯一能引起人类疾病的红病毒属成员。最近发现的几种与 B19 有相当大序列差异的菌株表明，细小病毒基因型可分为 1 型（B19）、2 型（A-6 和 LaLi）和 3 型（V9）。在它们的整个 DNA 序列中，这三种基因型的差异约为 10%。在这里，我们报告了在巴西圣保罗进行的一项前瞻性研究中分离到的一种命名为 BR543 的 3 型相关株。对 BR543 的近乎全长基因组序列的分析表明，这种 B19 变体序列与来自加纳的属于 3b 亚型的 Gh2768 菌株聚类，并且显示出大多数同义替换。