Klein Joern
Norwegian University of Science and Technology, Faculty of Medicine, Department of Cancer Research and Molecular Medicine, N-7489 Trondheim, Norway.
Infect Genet Evol. 2009 Mar;9(2):153-61. doi: 10.1016/j.meegid.2008.11.005. Epub 2008 Nov 28.
The use of molecular epidemiology is an important tool in understanding and consequently controlling FMDV. In this review I will present basic information about the disease, needed to perform molecular epidemiology. I will give a short introduction to the history and impact of foot-and-mouth disease, clinical picture, infection route, subclinical and persistent infections, general aspects of the transmission of FMDV, serotype-specific epidemiological characteristics, field epidemiology of FMDV, evolution and molecular epidemiology of FMDV. This is followed by two chapters describing the molecular epidemiology of foot-and-mouth disease in global surveillance and molecular epidemiology of foot-and-mouth disease in outbreak investigation.
分子流行病学的应用是了解并进而控制口蹄疫病毒的一项重要工具。在本综述中，我将介绍开展分子流行病学所需的有关该疾病的基础信息。我将简要介绍口蹄疫的历史与影响、临床症状、感染途径、亚临床感染与持续性感染、口蹄疫病毒传播的一般情况、血清型特异性流行病学特征、口蹄疫病毒的现场流行病学、口蹄疫病毒的进化与分子流行病学。接下来的两章将分别描述全球监测中的口蹄疫分子流行病学以及疫情调查中的口蹄疫分子流行病学。
