民族药理学与疟疾：新的假说线索还是古老有效的抗疟药物？

Ethnopharmacology and malaria: new hypothetical leads or old efficient antimalarials?

作者信息

Bourdy G, Willcox M L, Ginsburg H, Rasoanaivo Ph, Graz B, Deharo E

机构信息

Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR-152 (IRD - Université Paul Sabatier, Université de Toulouse 3), Mission IRD, Casilla 18-1209, Lima 18, Peru.

出版信息

Int J Parasitol. 2008 Jan;38(1):33-41. doi: 10.1016/j.ijpara.2007.07.004. Epub 2007 Jul 20.

DOI:10.1016/j.ijpara.2007.07.004

PMID:17720165

Abstract

New treatments are urgently needed to curb and eradicate malaria in developing countries. As most people living in malarial endemic areas use traditional medicine to fight this disease, why have new treatments not emerged recently from ethnopharmacology-oriented research? The rationale and limitations of the ethnopharmacological approach are discussed in this paper, focusing on ethnopharmacology methodologies and techniques used for assessing botanical samples for their antimalarial properties. Discrepancies often observed between strong ethnopharmacological reputation and laboratory results are discussed, as well as new research perspectives.

摘要

在发展中国家，迫切需要新的治疗方法来控制和根除疟疾。由于大多数生活在疟疾流行地区的人使用传统药物来对抗这种疾病，为什么最近没有从以民族药理学为导向的研究中出现新的治疗方法呢？本文讨论了民族药理学方法的原理和局限性，重点关注用于评估植物样本抗疟特性的民族药理学方法和技术。文中还讨论了民族药理学声誉与实验室结果之间经常出现的差异，以及新的研究前景。