Osborn David P J, Nazareth Irwin, King Michael B
Department of Mental Health Sciences, (Hampstead Campus), Royal Free and University College Medical School, London, UK.
Soc Psychiatry Psychiatr Epidemiol. 2007 Oct;42(10):787-93. doi: 10.1007/s00127-007-0247-3. Epub 2007 Aug 24.
Evidence regarding Coronary Heart Disease (CHD) related lifestyle in people with severe mental illnesses (SMI) such as schizophrenia is sparse. We aimed to quantify adverse CHD knowledge, diet and exercise in a representative primary care sample, and to determine whether socio-economic deprivation explained any findings.
We compared CHD lifestyle and CHD knowledge in 74 people with SMI and 148 without from seven general practices. We measured CHD knowledge, dietary fibre, fats and exercise using validated instruments and adjusted for socio-economic status.
Fewer people with SMI had higher CHD knowledge: OR 0.49 (95% CI: 0.27-0.88), higher total exercise scores 0.49 (0.27-0.86), higher fibre 0.46 (0.26-0.82) or lower saturated fat diets 0.53 (0.30-0.94). These results were stable irrespective of antipsychotic medication, socio-economic status or type of statistical analysis.
High fat, low fibre diets, lack of exercise and smoking are the likely causes of the majority of CHD in this high-risk group, irrespective of medication and socio-economic deprivation. This lifestyle and particularly the lower CHD knowledge provides a theoretical focus for more comprehensive preventative CHD interventions in SMI.
关于精神分裂症等严重精神疾病（SMI）患者与冠心病（CHD）相关生活方式的证据稀少。我们旨在对一个具有代表性的初级保健样本中不良的冠心病知识、饮食和运动进行量化，并确定社会经济剥夺是否能解释任何研究结果。
我们比较了来自7家普通诊所的74名SMI患者和148名非SMI患者的冠心病生活方式和冠心病知识。我们使用经过验证的工具测量了冠心病知识、膳食纤维、脂肪和运动情况，并对社会经济地位进行了调整。
SMI患者中拥有较高冠心病知识的人数较少：比值比为0.·49（95%置信区间：0.27 - 0.88），总运动得分较高的比例为0.49（0.27 - 0.86），膳食纤维较高的比例为0.46（0.26 - 0.82），饱和脂肪饮食较低的比例为0.53（0.30 - 0.94）。无论抗精神病药物、社会经济地位或统计分析类型如何，这些结果都是稳定的。
高脂肪、低纤维饮食、缺乏运动和吸烟可能是这个高危群体中大多数冠心病的病因，与药物治疗和社会经济剥夺无关。这种生活方式，尤其是较低的冠心病知识，为在SMI患者中开展更全面的冠心病预防干预提供了理论重点。
