Bennett Terry, Szatmari Peter, Bryson Susan, Volden Joanne, Zwaigenbaum Lonnie, Vaccarella Liezanne, Duku Eric, Boyle Michael
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
J Autism Dev Disord. 2008 Apr;38(4):616-25. doi: 10.1007/s10803-007-0428-7. Epub 2007 Aug 25.
Asperger syndrome (AS) is differentiated from high-functioning autism (HFA) largely on a history of "language delay." This study examined "specific language impairment" as a predictor of outcome. Language skills of 19 children with AS and 45 with HFA were assessed at 4-6 years of age (Time 1) and 2 years later (Time 2). Children's symptoms and functional outcome scores were assessed every 2 years (Times 3, 4, and 5) until ages 15-17 years old. Regression analysis revealed that specific language impairment at time 2 more often accounted for the greatest variation in outcome scores in adolescence than the standard diagnosis of AS versus HFA based on history of language delay. Diagnostic implications are discussed.
阿斯伯格综合征(AS)与高功能自闭症(HFA)的区分主要基于“语言发育迟缓”病史。本研究将“特定语言障碍”作为预后的预测指标进行了考察。对19名患有阿斯伯格综合征的儿童和45名患有高功能自闭症的儿童在4至6岁时(时间1)以及两年后(时间2)的语言技能进行了评估。每两年(时间3、4和5)对儿童的症状和功能预后评分进行评估,直至15至17岁。回归分析显示,与基于语言发育迟缓病史的阿斯伯格综合征与高功能自闭症的标准诊断相比,时间2时的特定语言障碍更常导致青少年预后评分的最大差异。文中还讨论了诊断意义。