Brodaty H, Peters K, Boyce P, Hickie I, Parker G, Mitchell P, Wilhelm K
Academic Department of Psychogeriatrics, University of New South Wales, Australia.
J Affect Disord. 1991 Nov;23(3):137-49. doi: 10.1016/0165-0327(91)90026-o.
The interaction of age and depression was investigated by comparing differences between elderly (greater than or equal to 60 years old) and younger consecutive in- and out-patient referrals to a tertiary referral mood disorders unit. Older patients with unipolar major depressive episode were more likely to be psychotic and agitated regardless of depressive subtype and less likely to have personality inadequacies or a family history of affective disorder. In this sample, elderly depressives' rating of diagnosis, severity, endogeneity and social impairment were similar, irrespective of age of first onset of depression, but a positive family history and personality abnormalities were less likely in late-onset depressives.
通过比较连续转诊至三级转诊情绪障碍科的老年患者（年龄大于或等于60岁）和年轻患者之间的差异，对年龄与抑郁症的相互作用进行了研究。患有单相重度抑郁发作的老年患者，无论抑郁亚型如何，更有可能出现精神病性症状和激越，且不太可能存在人格缺陷或情感障碍家族史。在这个样本中，老年抑郁症患者对诊断、严重程度、内源性和社会功能损害的评分相似，与首次发病年龄无关，但晚发性抑郁症患者有阳性家族史和人格异常的可能性较小。
