Science. 1978 Jun 30;200(4349):1499-500. doi: 10.1126/science.200.4349.1499.
The 1-benzoyl-3-phenylurea insecticide diflubenzuron is a potent inhibitor for the conversion of (14)C-labeled glucose to (14)C-labeled chitin in isolated abdomens of newly emerged adult milkweed bugs (Oncopeltus fasciatus Dallas). The inhibitory activity of 24 diflubenzuron analogs in this in vitro chitin-synthesizing system is in good agreement with their toxicity to fifth instar nymphs of this species. These insecticides act quickly and directly within the integument to ultimately block the terminal polymerization step in chitin formation.
1-苯甲酰基-3-苯基脲杀虫剂除虫脲是一种强效抑制剂，可抑制新羽化的成年美洲棉铃象（Oncopeltus fasciatus Dallas）离体腹部（14）C 标记葡萄糖转化为（14）C 标记几丁质。在这种体外几丁质合成系统中，24 种除虫脲类似物的抑制活性与其对该物种第五龄若虫的毒性非常吻合。这些杀虫剂在表皮内迅速而直接地发挥作用，最终阻止了几丁质形成中的末端聚合步骤。
