Roe Barbara, Coughlan Suzie, Hassan Jaythoon, Grogan Anne, Farrell Gillian, Norris Suzanne, Bergin Colm, Hall William W
Centre for Research in Infectious Diseases, University College Dublin, Dublin, Ireland.
J Infect Dis. 2007 Oct 1;196(7):1053-7. doi: 10.1086/520935. Epub 2007 Aug 21.
Coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is associated with an accelerated course of HCV infection and a faster progression to severe liver disease. We have investigated whether the development of liver disease in coinfected patients is associated with specific chemokine and cytokine production. Four cohorts--HCV/HIV-coinfected patients, HCV-monoinfected patients, HIV-monoinfected patients, and healthy control subjects--were studied. Serum levels of the 10-kDa interferon- gamma -inducible protein (IP-10) were higher in all 3 groups of infected patients than in control subjects (P<.0001). HCV/HIV-coinfected patients had significantly higher IP-10 levels than monoinfected patients. In HCV-monoinfected patients, liver fibrosis scores and liver enzyme levels were positively correlated with IP-10 levels. Elevated IP-10 levels are associated with and may contribute to liver damage in both HCV-monoinfected and HCV/HIV-coinfected patients.
丙型肝炎病毒（HCV）与人类免疫缺陷病毒（HIV）合并感染与HCV感染病程加速及更快进展至严重肝病有关。我们研究了合并感染患者肝病的发展是否与特定趋化因子和细胞因子的产生有关。研究了四个队列——HCV/HIV合并感染患者、HCV单一感染患者、HIV单一感染患者和健康对照者。所有3组感染患者血清中10 kDa干扰素γ诱导蛋白（IP-10）水平均高于对照者（P<0.0001）。HCV/HIV合并感染患者的IP-10水平显著高于单一感染患者。在HCV单一感染患者中，肝纤维化评分和肝酶水平与IP-10水平呈正相关。IP-10水平升高与HCV单一感染和HCV/HIV合并感染患者的肝损伤有关，并可能导致肝损伤。
