眼压与动脉血压的相关性：北京眼病研究

Intraocular pressure correlated with arterial blood pressure: the beijing eye study.

作者信息

Xu Liang, Wang Han, Wang Yaxing, Jonas Jost B

机构信息

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China.

出版信息

Am J Ophthalmol. 2007 Sep;144(3):461-2. doi: 10.1016/j.ajo.2007.05.013.

DOI:10.1016/j.ajo.2007.05.013

PMID:17765433

Abstract

PURPOSE

To assess the relation of arterial blood pressure (BP) and intraocular pressure (IOP) in an adult population not using glaucoma medications.

DESIGN

Cross-sectional population-based study.

METHODS

The Beijing Eye Study 2006, a population-based, cross-sectional cohort study, included 3,253 subjects (age, 45 years or more). The mean age was 60.4 +/- 10.1 years. Seated BP and applanation tonometric IOP were measured, and their relation was assessed in regression models.

RESULTS

After exclusion of subjects who had closed anterior chamber angles and an IOP of more than 21 mm Hg or who were receiving topical antiglaucomatous treatment, the study included 2,981 subjects. In multivariate regression analysis, IOP was correlated significantly with systolic BP (P < .001; 95% confidence interval [CI], 0.011 to 0.022), diastolic BP (P < .001; 95% CI, 0.008 to 0.029), central corneal thickness (P < .001; 95% CI, 0.031 to 0.037), and myopic refractive error (P = .006; 95% CI, -0.103 to -0.015). Neither age (P = .17) nor body mass index (P = .20) were significantly associated with IOP.

CONCLUSIONS

IOP is associated significantly with systolic and diastolic BP.

摘要

目的

评估未使用青光眼药物的成年人群中动脉血压（BP）与眼内压（IOP）之间的关系。

设计

基于人群的横断面研究。

方法

2006年北京眼病研究是一项基于人群的横断面队列研究，纳入了3253名受试者（年龄45岁及以上）。平均年龄为60.4±10.1岁。测量坐位血压和压平眼压计测量的眼压，并在回归模型中评估它们之间的关系。

结果

排除前房角关闭、眼压高于21 mmHg或正在接受局部抗青光眼治疗的受试者后，该研究纳入了2981名受试者。在多变量回归分析中，眼压与收缩压显著相关（P <.001；95%置信区间[CI]，0.011至0.022）、舒张压（P <.001；95% CI，0.008至0.029）、中央角膜厚度（P <.001；95% CI，0.031至0.037）和近视屈光不正（P =.006；95% CI，-0.103至-0.015）。年龄（P =.17）和体重指数（P =.20）均与眼压无显著相关性。