Whishaw I Q, Tomie J A
Department of Psychology, University of Lethbridge, Alberta, Canada.
Behav Neurosci. 1991 Dec;105(6):787-97. doi: 10.1037//0735-7044.105.6.787.
Hippocampal rats were given simple, conditional, and configural tasks that required them to pull up strings to obtain food pellets. The tasks contrasted string size, odor, location, paired string size and location, or compounds of string size and odor. There was no anterograde or retrograde amnesia for the simple discriminations or for simple discrimination components of the other tasks. Hippocampal rats also learned conditional and configural tasks, although they were impaired on the configural task. Finally, the rats were impaired in postoperative retention of the conditional but not the configural task, although they displayed savings in relation to naive rats on the conditional task. The results do not support theories that the hippocampus is essential for conditional or configural learning but may support a modified form of configural theory in which the hippocampus contributes to, but is not essential for, learning or retention of configurations.
给海马体受损的大鼠布置了简单、条件性和构型任务，要求它们拉起绳子以获取食物颗粒。这些任务在绳子大小、气味、位置、配对的绳子大小和位置，或绳子大小与气味的组合方面形成对比。对于简单辨别或其他任务的简单辨别成分，不存在顺行性或逆行性遗忘。海马体受损的大鼠也学会了条件性和构型任务，尽管它们在构型任务上表现受损。最后，大鼠在术后对条件性任务的记忆保持方面受损，但对构型任务没有受损，尽管它们在条件性任务上相对于未经历过训练的大鼠表现出节省效应。这些结果不支持海马体对条件性或构型学习至关重要的理论，但可能支持构型理论的一种修正形式，即海马体对构型的学习或记忆有贡献，但不是必不可少的。
