Alvarado M C, Rudy J W
Department of Psychology, University of Colorado, Boulder 80309, USA.
Behav Neurosci. 1995 Apr;109(2):204-11. doi: 10.1037//0735-7044.109.2.204.
We assessed the effects of hippocampal-formation (HF) damage on the rat's ability to learn two sets of concurrent visual discriminations. Each set included three problems. One set, called the transverse-patterning problem, was constructed so that each choice stimulus was ambiguous; sometimes it was the correct (+) and sometimes it was the incorrect (-) choice as follows: A+ vs. B-, B+ vs. C-, and C+ vs. A-. It could not be solved unless rats used configural associations. The stimuli were not ambiguous in the second, elemental problem set, A+ vs. B-, C+ vs. D-, and E+ vs. F-. Rats could solve this set without the use of configural associations. Rats with HF damage solved the set of elemental problems, but their performance on the transverse-patterning problem was impaired. These results support Sutherland and Rudy's (1989) theory that the hippocampal formation is critical for the acquisition of configural associations.
我们评估了海马结构（HF）损伤对大鼠学习两组同时进行的视觉辨别能力的影响。每组包括三个问题。其中一组称为横向模式问题，其构建方式使得每个选择刺激都是模糊的；有时它是正确的（+）选择，有时它是错误的（-）选择，如下所示：A+对B-，B+对C-，以及C+对A-。除非大鼠使用构型关联，否则无法解决这个问题。在第二个基本问题组中，刺激并不模糊，即A+对B-，C+对D-，以及E+对F-。大鼠可以在不使用构型关联的情况下解决这组问题。患有HF损伤的大鼠解决了基本问题组，但它们在横向模式问题上的表现受到了损害。这些结果支持了萨瑟兰和鲁迪（1989）的理论，即海马结构对于构型关联的习得至关重要。
