对小鼠单纯疱疹病毒和埃可病毒感染的干扰素联合保护作用及干扰素诱导作用
Combined protective effects on interferon and interferon induction on herpes simplex and ectromelia virus infections in mice.
作者信息
Imanishi J, Matsubara M, Won C J, Nomura H, Kishida T
出版信息
Antimicrob Agents Chemother. 1981 May;19(5):922-4. doi: 10.1128/AAC.19.5.922.
Abstract
Mouse interferon or the induction of mouse interferon with polyriboinosinic acid-polyribocytidylic acid significantly protected mice against herpes simplex and ectromelia viral infections. When polyriboinosinic acid-polyribocytidylic acid was administered 24 h before herpes simplex or ectromelia viral infection and mouse interferon was administered shortly before and 24 h after infection, a combined protective effect against either herpes simplex or ectromelia viral infection in mice was evident. There was a significant decrease in the mortality rate with the combined treatment as compared either with the rate in group treated with interferon or polyriboinosinic acid-polyribocytidylic acid.
摘要
小鼠干扰素或用聚肌苷酸-聚胞苷酸诱导产生的小鼠干扰素能显著保护小鼠免受单纯疱疹病毒和埃可病毒感染。当在单纯疱疹病毒或埃可病毒感染前24小时给予聚肌苷酸-聚胞苷酸，并在感染前不久及感染后24小时给予小鼠干扰素时，对小鼠单纯疱疹病毒或埃可病毒感染的联合保护作用明显。与单独使用干扰素或聚肌苷酸-聚胞苷酸治疗的组相比，联合治疗的死亡率显著降低。
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