Grower M F, Lyon D R, Levin M P, Chandler D W
J Oral Pathol. 1975 Dec;4(6):291-6. doi: 10.1111/j.1600-0714.1975.tb01746.x.
Gingival fluid samples were collected from 12 healthy adult women who ranged in age from 19 to 34 years. Seven subjects with normal menstrual cycles who received no medications acted as controls while five subjects who had been using oral contraceptives for a minimum of 17 months constituted the experimental group. The women using birth control pills showed a 53% increase in the gingival fluid volume versus the controls. Radioimmunoassay revealed a mean concentration of cyclic adenosine monophosphate (cAMP) in the gingival fluid of 3.8-10(-6)M in the controls and 1.9-10(-6)M in subjects using oral contraceptives, although the total amount of cAMP present in the fluid from both groups was equal. These gingival fluid cAMP levels were a hundredfold higher than those measured in serum and saliva.
从12名年龄在19至34岁之间的健康成年女性中采集龈沟液样本。7名月经周期正常且未服用任何药物的受试者作为对照组，而5名至少使用口服避孕药17个月的受试者构成实验组。使用避孕药的女性龈沟液量比对照组增加了53%。放射免疫分析显示，对照组龈沟液中环状单磷酸腺苷（cAMP）的平均浓度为3.8×10⁻⁶M，使用口服避孕药的受试者中为1.9×10⁻⁶M，尽管两组龈沟液中cAMP的总量相等。这些龈沟液中的cAMP水平比血清和唾液中测得的水平高100倍。
