Andersson R, Foss A
Department of Surgery, Lund University, Sweden.
Hepatogastroenterology. 1991 Dec;38(6):547-9.
A standardized 2/3 liver resection was performed in the rat. One and seven days following liver resection, gram-negative sepsis was induced by cecal ligation and puncture (CLP). Mortality significantly increased following CLP one day after hepatectomy, but no difference was to be seen after seven days as compared with sham operated animals. Clearance of radiolabeled heat-killed 125I E. coli injected intravenously was significantly decreased one day following liver resection, but not after seven days. The capability of bacterial clearance and survival correlated well with the increase in weight of the liver remnant following liver resection, as did organ uptake of radiolabeled bacteria within the liver, spleen and lungs, as a measure of reticuloendothelial system function. Splenic and pulmonary uptake initially increased following liver resection, but normalized within seven days. In conclusion, the present study shows that the liver is responsible for most of the reticuloendothelial system function and that a major liver resection increases the risk of fatal outcome before regeneration of the liver remnant has occurred, despite normal function of the residual liver tissue.
在大鼠中进行标准化的2/3肝切除术。肝切除术后1天和7天，通过盲肠结扎和穿刺（CLP）诱导革兰氏阴性菌败血症。肝切除术后1天CLP后死亡率显著增加，但与假手术动物相比，7天后未见差异。肝切除术后1天，静脉注射的放射性标记热灭活125I大肠杆菌的清除率显著降低，但7天后未降低。细菌清除能力和存活率与肝切除术后肝残余重量的增加密切相关，肝脏、脾脏和肺内放射性标记细菌的器官摄取也是如此，以此作为网状内皮系统功能的指标。肝切除术后脾脏和肺部摄取最初增加，但在7天内恢复正常。总之，本研究表明肝脏负责大部分网状内皮系统功能，并且在肝残余再生发生之前，尽管残余肝组织功能正常，但大的肝切除术会增加致命结局的风险。
