Amarapurkar Deepak, Kamani Prafull, Patel Nikhil, Gupte Parijat, Kumar Pravin, Agal Subhash, Baijal Rajiv, Lala Somesh, Chaudhary Dinesh, Deshpande Anjali
Department of Gastroenterology, Jagjivanram Western Railway Hospital, Mumbai.
Ann Hepatol. 2007 Jul-Sep;6(3):161-3.
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and liver transplantation in western countries. Increasing incidence of NAFLD has been well documented from Asian countries like Japan and China. Diabetes mellitus (DM), obesity, hyperinsulinemia are predisposing factors for NAFLD. There is increase in incidence of DM, obesity and insulin resistance in India in last two decades. Hence it is logical to expect increase in incidence of NAFLD in India. There is limited data on the prevalence of NAFLD from India. Majority of data comes from hospital based studies including small number of patients. Therefore this study was planned to estimate the prevalence of NAFLD in general population.
Residents of two Railway colonies were evaluated on history, clinical examination, anthropometric measurements, biochemical tests and abdominal ultrasound.
1,168 participants were evaluated. Persons with any amount of alcohol consumption, HBs Ag positive, Anti HCV positive, persons with other known liver diseases and taking medications causing liver disease were excluded. Prevalence of NAFLD on ultrasound was 16.6%. Out of 730 subjects above the age of 20 years (341 male 384 female 389) mean age 39.08 +/- 12.3 years, 4% had diabetes, 57% had central obesity. Prevalence of NAFLD based on the ultrasound above 20 years of age was 18.9%. NAFLD was more prevalent in male than female (24.6% vs 13.6%, p < 0.001). Risk factors associated with NAFLD were age more than 40 years, male gender, central obesity, high BMR > 25, elevated fasting blood sugar, raised AST and ALT.
Prevalence of NAFLD in Indian population is comparable to the west.
非酒精性脂肪性肝病（NAFLD）是西方国家慢性肝病和肝移植的常见病因。在日本和中国等亚洲国家，NAFLD发病率上升的情况已有充分记录。糖尿病（DM）、肥胖、高胰岛素血症是NAFLD的诱发因素。在过去二十年中，印度的糖尿病、肥胖和胰岛素抵抗发病率有所上升。因此，预计印度NAFLD的发病率也会上升。来自印度的NAFLD患病率数据有限。大多数数据来自基于医院的研究，且患者数量较少。因此，本研究旨在估计普通人群中NAFLD的患病率。
对两个铁路职工聚居区的居民进行了病史、临床检查、人体测量、生化检测和腹部超声检查。
共评估了1168名参与者。排除了有任何饮酒量、乙肝表面抗原阳性、丙肝抗体阳性、患有其他已知肝病以及正在服用导致肝病药物的人员。超声检查显示NAFLD的患病率为16.6%。在730名20岁以上的受试者中（男性341名，女性389名，平均年龄39.08±12.3岁），4%患有糖尿病，57%有中心性肥胖。20岁以上人群基于超声检查的NAFLD患病率为18.9%。NAFLD在男性中比女性更普遍（24.6%对13.6%，p<0.001）。与NAFLD相关的危险因素包括年龄超过40岁、男性、中心性肥胖、基础代谢率>25、空腹血糖升高、谷草转氨酶和谷丙转氨酶升高。
印度人群中NAFLD的患病率与西方相当。
