Duggan C F, Sham P, Lee A S, Murray R M
Department of Psychological Medicine, Institute of Psychiatry, London.
Psychol Med. 1991 Nov;21(4):985-90. doi: 10.1017/s0033291700029974.
The hypothesis that recurrent or chronic depressive illness produces a long-term change in neuroticism was examined in a sample (N = 34) from a consecutive series of 89 depressed patients admitted to the Maudsley Hospital in 1965/6. The Eysenck Personality Inventory (EPI) was administered at the time of the index illness both when the patients were depressed and on recovery, and then again at follow-up 18 years later. The change in the neuroticism (N) score over the 18-year-period was compared in good and poor outcome groups defined variously by a global rating of outcome, frequency of episodes, extent of subsequent hospitalization and the presence or absence of subsequent chronicity. The mean N score for the sample as a whole did not change significantly over the 18 years, and no differential change in the N score was observed between any of the good and poor outcome groups. Thus, the hypothesis was not supported.
对复发性或慢性抑郁症会导致神经质产生长期变化这一假设，在1965/6年入住莫兹利医院的89例连续抑郁症患者样本（N = 34）中进行了检验。艾森克人格问卷（EPI）在首次患病时、患者抑郁时以及康复时进行施测，然后在18年后的随访时再次施测。根据总体结局评分、发作频率、后续住院时间长短以及是否存在后续慢性病程等不同方式定义的预后良好组和预后不良组，比较了18年间神经质（N）得分的变化。整个样本的平均N得分在18年间没有显著变化，在任何预后良好组和预后不良组之间也未观察到N得分的差异变化。因此，该假设未得到支持。
