Duggan C F, Lee A S, Murray R M
Genetics Section, Institute of Psychiatry, Denmark Hill, London.
Br J Psychiatry. 1990 Jul;157:19-24. doi: 10.1192/bjp.157.1.19.
In 1965/66, a consecutive series of 89 in-patients with depression were interviewed, given two personality tests (the EPI and LOI), and were accorded a score on a neurotic-psychotic continuum (DI). Eighteen years later, the series was followed up and the predictive power of the original data was determined. High neuroticism scores on the EPI on recovery and particularly when ill but referring to the pre-morbid state were associated with poor overall outcome and chronicity. High obsessional interference scores on the LOI on recovery were also associated with poor long-term outcome, impaired social adjustment, more time spent in hospital, and with the subsequent development of schizophrenic or schizoaffective episodes. High psychotic scores on the DI were also associated with poor long-term outcome, a greater length of time spent in hospital, and with bipolar affective disorder, and this effect was independent of the personality measures.
1965年至1966年期间，对连续收治的89名抑郁症住院患者进行了访谈，让他们接受两项人格测试（艾森克人格问卷和莱斯特强迫观念量表），并在神经症-精神病连续体（抑郁指数）上给出一个分数。18年后，对该系列患者进行了随访，并确定了原始数据的预测能力。艾森克人格问卷中康复时尤其是患病时（但指病前状态）的高神经质得分与总体预后不良和慢性病程相关。莱斯特强迫观念量表中康复时的高强迫观念干扰得分也与长期预后不良、社会适应受损、住院时间延长以及随后精神分裂症或分裂情感性发作的发生相关。抑郁指数中的高精神病得分也与长期预后不良、住院时间更长以及双相情感障碍相关，而且这种影响独立于人格测量指标。
