Lee Min Joung, Lee Sang Mok, Lee Hyun Ju, Wee Won Ryang, Lee Jin Hak, Kim Mee Kum
Department of Ophthalmology, Seoul National University College of Medicine, and Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Korea.
Korean J Ophthalmol. 2007 Sep;21(3):131-6. doi: 10.3341/kjo.2007.21.3.131.
To compare forward shift of posterior corneal surface and higher-order aberration (HOA) changes after LASIK, LASEK, and wavefront-guided LASEK surgery in moderate myopia
One hundred eighty four eyes undergoing LASIK, LASEK and wavefront-guided LASEK with VISX STAR S4 were included in this study. The posterior corneal elevation was measured with Orbscan before, 2 and 4 months after surgery. Changes of the elevation were assessed using the difference map generated from preoperative and postoperative elevation maps. The values of higher-order aberrations were evaluated preoperatively and 2 months postoperatively with Wavefront aberrometer.
The posterior corneal surface displayed forward shift of 27.2+/-11.45 micrometer, 24.3+/-9.76 micrometer in LASIK group, 23.4+/-10.5 micrometer, 23.6+/10.55 micrometer in LASEK group, 24.0+/-14.95 micrometer, 28.4+/-14.72 micrometer in wavefront-guided LASEK group at 2 months and 4 months, respectively. There were no statistically significant differences among those three groups, and between 2 and 4 months. The root mean score (RMS) of HOA was increased after LASIK and LASEK (p=0.000, p=0.000, respectively). The mean change of HOA-RMS was significantly smaller in wavefront-guided LASEK than LASIK or LASEK (p=0.000, p=0.000, respectively, Bonferroni-corrected).
The changes of posterior corneal surface forward shift showed no difference among LASIK, LASEK and wavefront-guided LASEK in moderate myopia. HOAs were significantly increased after LASIK and LASEK. The changes of HOAs were significant smaller in wavefront-guided LASEK than LASIK or LASEK.
比较准分子原位角膜磨镶术（LASIK）、准分子上皮下角膜磨镶术（LASEK）和波前像差引导的LASEK手术治疗中度近视后角膜后表面的前向移位及高阶像差（HOA）的变化
本研究纳入了184例行LASIK、LASEK及使用VISX STAR S4的波前像差引导LASEK手术的眼。术前、术后2个月及4个月使用Orbscan测量角膜后表面高度。使用术前和术后高度图生成的差异图评估高度变化。术前及术后2个月使用波前像差仪评估高阶像差的值。
LASIK组术后2个月和4个月角膜后表面前向移位分别为27.2±11.45微米、24.3±9.76微米；LASEK组分别为23.4±10.5微米、23.6±10.55微米；波前像差引导的LASEK组分别为24.0±14.95微米、28.4±14.72微米。三组之间以及术后2个月和4个月之间差异均无统计学意义。LASIK和LASEK术后HOA的均方根值（RMS）增加（p值分别为0.000、0.000）。波前像差引导的LASEK术后HOA-RMS的平均变化显著小于LASIK或LASEK（经Bonferroni校正后，p值分别为0.000、0.000）。
中度近视患者中，LASIK、LASEK和波前像差引导的LASEK术后角膜后表面前向移位的变化无差异。LASIK和LASEK术后HOA显著增加。波前像差引导的LASEK术后HOA的变化显著小于LASIK或LASEK。
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