Nieman David C, Henson Dru A, Gross Sarah J, Jenkins David P, Davis J Mark, Murphy E Angela, Carmichael Martin D, Dumke Charles L, Utter Alan C, McAnulty Steven R, McAnulty Lisa S, Mayer Eugene P
Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA.
Med Sci Sports Exerc. 2007 Sep;39(9):1561-9. doi: 10.1249/mss.0b013e318076b566.
To investigate the effects of quercetin supplementation on incidence of upper respiratory tract infections (URTI) and exercise-induced changes in immune function.
Trained male cyclists (N=40) were randomized to quercetin (N=20) or placebo (N=20) groups and, under double-blind procedures, received 3 wk quercetin (1000 mg.d(-1)) or placebo before, during, and for 2 wk after a 3-d period in which subjects cycled for 3 h.d(-1) at approximately 57% Wmax. Blood and saliva samples were collected before and after each of the three exercise sessions and assayed for natural killer cell activity (NKCA), PHA-stimulated lymphocyte proliferation (PHA-LP), polymorphonuclear oxidative-burst activity (POBA), and salivary IgA output (sIgA).
Pre- to postexercise changes in NKCA, PHA-LP, POBA, and sIgA did not differ significantly between quercetin and placebo groups. URTI incidence during the 2-wk postexercise period differed significantly between groups (quercetin=1/20 vs placebo=9/20, Kaplan-Meier analysis statistic=8.31, P=0.004).
Quercetin versus placebo ingestion did not alter exercise-induced changes in several measures of immune function, but it significantly reduced URTI incidence in cyclists during the 2-wk period after intensified exercise.
研究补充槲皮素对上呼吸道感染（URTI）发病率及运动诱导的免疫功能变化的影响。
将经过训练的男性自行车运动员（N = 40）随机分为槲皮素组（N = 20）和安慰剂组（N = 20），在双盲程序下，在为期3天的运动期间（受试者每天以约57%最大摄氧量的强度骑行3小时）、运动期间及运动后2周，给予槲皮素组3周的槲皮素（1000 mg·d⁻¹）或安慰剂组安慰剂。在三次运动前后采集血液和唾液样本，检测自然杀伤细胞活性（NKCA）、PHA刺激的淋巴细胞增殖（PHA-LP）、多形核细胞氧化爆发活性（POBA）和唾液IgA分泌量（sIgA）。
槲皮素组和安慰剂组运动前后NKCA、PHA-LP、POBA和sIgA的变化无显著差异。运动后2周期间，两组URTI发病率有显著差异（槲皮素组 = 1/20，安慰剂组 = 9/20，Kaplan-Meier分析统计量 = 8.31，P = 0.004）。
摄入槲皮素与安慰剂相比，并未改变运动诱导的多项免疫功能指标的变化，但在强化运动后的2周内，显著降低了自行车运动员的URTI发病率。
