病毒载量作为克里米亚-刚果出血热预后的预测指标
Viral load as a predictor of outcome in Crimean-Congo hemorrhagic fever.
作者信息
Cevik Mustafa Aydin, Erbay Ayşe, Bodur Hürrem, Eren Selim Sirri, Akinci Esragül, Sener Kenan, Ongürü Pinar, Kubar Ayhan
机构信息
Infectious Diseases and Clinical Microbiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
出版信息
Clin Infect Dis. 2007 Oct 1;45(7):e96-100. doi: 10.1086/521244. Epub 2007 Aug 23.
Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal disease affecting multiple organ systems. To determine the association between viral load and severity of CCHF infection, quantitative measurement of CCHF virus was performed using 1-step reverse-transcriptase polymerase chain reaction for 36 patients with CCHF infection. Viral loads ranged from 1.1x10(3) copies/mL to > or = 9.9x10(9) copies/mL. Nine (25%) of 36 patients died. In 8 of the 9 patients with fatal outcomes, viral loads were detected that were > or = 1x10(9) copies/mL, whereas in 25 of the 26 patients with nonfatal outcomes, viral loads were detected that were < 1x10(9) copies/mL (P<.001). A viral load > or = 1x10(9) RNA copies/mL can be considered to predict a fatal outcome with a positive predictive value of 80%, with 88.9% sensitivity and 92.6% specificity. We suggest that viral load is a measure of the severity of CCHF.
克里米亚-刚果出血热（CCHF）是一种可能致命的疾病，可影响多个器官系统。为了确定病毒载量与CCHF感染严重程度之间的关联，对36例CCHF感染患者采用一步法逆转录聚合酶链反应进行了CCHF病毒的定量检测。病毒载量范围为1.1×10³拷贝/毫升至≥9.9×10⁹拷贝/毫升。36例患者中有9例（25%）死亡。在9例死亡患者中的8例中，检测到病毒载量≥1×10⁹拷贝/毫升，而在26例非致命结局患者中的25例中，检测到病毒载量＜1×10⁹拷贝/毫升（P＜0.001）。病毒载量≥1×10⁹RNA拷贝/毫升可被视为预测致命结局，其阳性预测值为80%，敏感性为88.9%，特异性为92.6%。我们认为病毒载量是CCHF严重程度的一个指标。
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