Brubaker R R, Beesley E D, Surgalla M J
Science. 1965 Jul 23;149(3682):422-4. doi: 10.1126/science.149.3682.422.
Loss of the genetic determinant for pesticin I in Pasteurella pestis results in concomitant loss of the plague coagulase and fibrinolytic factor. The median lethal dose for mice of an isolate lacking only these activities is increased by factors of about 10(1), 10(4), and 10(7) cells when administered by the intravenous, intraperitoneal, and subcutaneous routes, respectively. Virulence of the aforesaid strain can be enhanced in mice treated with 40 microg of ferrous iron. This response resembles that of Pasteurella pseudotuberculosis, a closely related species that normally lacks pesticin I.
鼠疫耶尔森氏菌中鼠疫菌素I的遗传决定因素缺失会导致鼠疫凝固酶和纤维蛋白溶解因子同时缺失。仅缺乏这些活性的分离株对小鼠的半数致死剂量，经静脉、腹腔和皮下途径给药时，分别增加约10¹、10⁴和10⁷个细胞。上述菌株在用40微克亚铁处理的小鼠中，毒力会增强。这种反应类似于假结核耶尔森氏菌，一种通常缺乏鼠疫菌素I的密切相关物种的反应。
