Greca F H, Souza-Filho Z A, Giovanini A, Rubin M R, Kuenzer R F, Reese F B, Araujo L M
Experimental Surgery Department, Pontifical Catholic University of Paraná, Paraná, Brazil.
Hernia. 2008 Feb;12(1):45-9. doi: 10.1007/s10029-007-0276-6. Epub 2007 Sep 7.
Two types of monofilament polypropylene mesh with different pore sizes, mass densities and burst strengths were used to repair two identical paired full-thickness abdominal wall defects in ten dogs, in order to compare their integration histology 90 days after implantation. On one side a standard mesh, Prolene (Ethicon), was sutured to the borders of the defect, while on the other a new ultralightweight macroporous mesh, Mpathy mesh, was used. There was a significantly greater densitometric proportion of mature (type I) collagen (58.38%) for Mpathy mesh compared to Prolene (34.05%, P=0.01). Although Prolene has 3.6 times the burst strength of Mpathy mesh, the implanted tissue strength was marginally greater for Mpathy mesh. We conclude that Mpathy mesh gives a surgical repair that is at least as strong as that provided by Prolene, along with a higher concentration of mature collagen and less fibrosis (P=0.07), in this canine histology model.
为了比较两种不同孔径、质量密度和抗破裂强度的单丝聚丙烯网片在植入90天后的整合组织学情况，研究人员使用它们对10只狗的两个相同的配对全层腹壁缺损进行修复。在一侧，将标准网片普理灵（Ethicon公司生产）缝合到缺损边缘，而在另一侧则使用一种新型超轻量多孔网片Mpathy网片。与普理灵网片（34.05%，P = 0.01）相比，Mpathy网片中成熟（I型）胶原蛋白的密度比例显著更高（58.38%）。尽管普理灵网片的抗破裂强度是Mpathy网片的3.6倍，但Mpathy网片植入后的组织强度略高。我们得出结论，在这个犬类组织学模型中，Mpathy网片提供的手术修复效果至少与普理灵网片一样好，同时成熟胶原蛋白浓度更高，纤维化程度更低（P = 0.07）。
