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Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2.通过猪肺炎支原体和2型猪圆环病毒双重感染在猪中实验性复制断奶后多系统消耗综合征
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Comparative efficacy of commercial Mycoplasma hyopneumoniae and porcine circovirus 2 (PCV2) vaccines in pigs experimentally infected with M. hyopneumoniae and PCV2.比较商业感染支原体肺炎和猪圆环病毒 2 （PCV2 ）疫苗在实验感染支原体肺炎和 PCV2 的猪中的功效。
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Effect of coinfection with genogroup 1 porcine torque teno virus on porcine circovirus type 2-associated postweaning multisystemic wasting syndrome in gnotobiotic pigs.1型猪圆环病毒与猪圆环病毒2型共感染对无菌猪断奶后多系统消耗综合征的影响。
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Effectiveness of porcine circovirus type 2 vaccination in reducing the severity of post-weaning multisystemic wasting syndrome in pigs.猪圆环病毒 2 型疫苗接种对降低猪断奶后多系统消耗综合征严重程度的效果。
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Revisiting Porcine Circovirus Infection: Recent Insights and Its Significance in the Piggery Sector.重新审视猪圆环病毒感染：最新见解及其在养猪业中的意义。
Vaccines (Basel). 2023 Jul 31;11(8):1308. doi: 10.3390/vaccines11081308.
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Development of Recombinase Aided Amplification Combined With Disposable Nucleic Acid Test Strip for Rapid Detection of Porcine Circovirus Type 2.重组酶辅助扩增结合一次性核酸检测试纸条用于快速检测猪圆环病毒2型的研究进展
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4
Porcine circovirus type 2 increases interleukin-1beta and interleukin-10 production via the MyD88-NF-kappa B signaling pathway in porcine alveolar macrophages .猪圆环病毒2型通过MyD88-NF-κB信号通路增加猪肺泡巨噬细胞中白细胞介素-1β和白细胞介素-10的产生。
J Vet Sci. 2017 Jun 30;18(2):183-191. doi: 10.4142/jvs.2017.18.2.183.
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Vaccination with a Porcine Reproductive and Respiratory Syndrome (PRRS) Modified Live Virus Vaccine Followed by Challenge with PRRS Virus and Porcine Circovirus Type 2 (PCV2) Protects against PRRS but Enhances PCV2 Replication and Pathogenesis Compared to Results for Nonvaccinated Cochallenged Controls.接种猪繁殖与呼吸综合征（PRRS）弱毒活疫苗后再用PRRS病毒和2型猪圆环病毒（PCV2）进行攻毒，与未接种疫苗的共同攻毒对照相比，可预防PRRS，但会增强PCV2的复制和致病性。
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Quantitative polymerase chain reaction for Porcine circovirus-2 in swine feces in a Porcine circovirus disease-affected commercial herd and a nonaffected commercial herd.在一个受猪圆环病毒病影响的商业猪群和一个未受影响的商业猪群中，对猪粪便中的猪圆环病毒2型进行定量聚合酶链反应检测。
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The piglet as a model for B cell and immune system development.仔猪作为B细胞和免疫系统发育的模型。
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本文引用的文献

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Features of porcine circovirus-2 disease: correlations between lesions, amount and distribution of virus, and clinical outcome.猪圆环病毒2型疾病的特征：病变、病毒数量和分布与临床结果之间的相关性
J Vet Diagn Invest. 2005 May;17(3):213-22. doi: 10.1177/104063870501700301.
2
Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2.通过猪肺炎支原体和2型猪圆环病毒双重感染在猪中实验性复制断奶后多系统消耗综合征
Vet Pathol. 2004 Nov;41(6):624-40. doi: 10.1354/vp.41-6-624.
3
Quantitation of porcine circovirus type 2 isolated from serum/plasma and tissue samples of healthy pigs and pigs with postweaning multisystemic wasting syndrome using a TaqMan-based real-time PCR.使用基于TaqMan的实时荧光定量PCR对从健康猪以及患有断奶后多系统消耗综合征的猪的血清/血浆和组织样本中分离出的2型猪圆环病毒进行定量分析。
J Virol Methods. 2004 Dec 15;122(2):171-8. doi: 10.1016/j.jviromet.2004.08.014.
4
Lack of an effect of a commercial vaccine adjuvant on the development of postweaning multisystemic wasting syndrome (PMWS) in porcine circovirus type 2 (PCV2) experimentally infected conventional pigs.一种商业疫苗佐剂对实验性感染2型猪圆环病毒（PCV2）的常规断奶仔猪断奶后多系统消耗综合征（PMWS）发展无影响。
Vet Res. 2004 Jan-Feb;35(1):83-90. doi: 10.1051/vetres:2003039.
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Porcine circovirus-2 and concurrent infections in the field.猪圆环病毒2型及田间并发感染
Vet Microbiol. 2004 Feb 4;98(2):159-63. doi: 10.1016/j.vetmic.2003.10.008.
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Association of porcine circovirus 2 with porcine respiratory disease complex.猪圆环病毒2型与猪呼吸道疾病综合征的关联
Vet J. 2003 Nov;166(3):251-6. doi: 10.1016/s1090-0233(02)00257-5.
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Myocarditis and abortion associated with intrauterine infection of sows with porcine circovirus 2.与猪圆环病毒2型宫内感染母猪相关的心肌炎和流产
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Effect of vaccination with selective bacterins on conventional pigs infected with type 2 porcine circovirus.用选择性菌苗接种对感染2型猪圆环病毒的常规猪的影响。
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In vitro studies on the infection and replication of porcine circovirus type 2 in cells of the porcine immune system.猪圆环病毒2型在猪免疫系统细胞中的感染与复制的体外研究
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Recent advances in veterinary vaccine adjuvants.兽医疫苗佐剂的最新进展。
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猪肺炎支原体疫苗与猪圆环病毒2型（PCV2）感染：在PCV2相关疾病的无菌猪模型中诱导断奶后多系统衰竭综合征（PMWS）

Mycoplasma hyopneumoniae bacterins and porcine circovirus type 2 (PCV2) infection: induction of postweaning multisystemic wasting syndrome (PMWS) in the gnotobiotic swine model of PCV2-associated disease.

作者信息

Krakowka Steven, Ellis John, McNeilly Francis, Waldner Cheryl, Rings D Michael, Allan Gordon

机构信息

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Western College of Veterinary Medicine, Columbus, USA.

出版信息

Can Vet J. 2007 Jul;48(7):716-24.

PMID:17824156
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1899844/
Abstract

Groups (5 to 15 per group) of gnotobiotic swine were infected oronasally with porcine circovirus type 2 (PCV2) at 3 days of age and then given 1 of 6 different commercial Mycoplasma hyopneumoniae (M. hyopneumoniae) bacterins as either a single dose (7 d of age, 1 application products) or 2 doses (7 and 21 d of age, 2 application product). Control groups received PCV2 alone (n = 9) or were infected with PCV2 and immunized twice with keyhole limpet hemocyanin (KLH) emulsified in incomplete Freund's adjuvant (ICFA) (n = 7). Five of 7 (71%) PCV2-infected piglets immunized with KLH/ICFA developed mild or overt PMWS, whereas none of 9 piglets infected with PCV2 alone developed PMWS. Five of 12 (42%) piglets vaccinated with a commercial bacterin containing mineral oil adjuvant developed PMWS following vaccination. None of the PCV2-infected piglets in the other bacterin-vaccinated groups developed PMWS in this model of PCV2-associated disease. This difference in prevalence of PMWS in piglets given the mineral oil-adjuvanted M. hyopneumoniae bacterin and the other M. hyopneumoniae bacterin vaccination groups was statistically significant (P < 0.05).

摘要

将无菌猪分成若干组（每组5至15头），在3日龄时经口鼻腔感染2型猪圆环病毒（PCV2），然后给予6种不同的市售猪肺炎支原体（M. hyopneumoniae）菌苗中的一种，给药方式为单剂量（7日龄，单次给药产品）或2剂量（7日龄和21日龄，两次给药产品）。对照组单独接受PCV2（n = 9），或感染PCV2并用不完全弗氏佐剂（ICFA）乳化的钥孔戚血蓝蛋白（KLH）免疫两次（n = 7）。7头用KLH/ICFA免疫的PCV2感染仔猪中有5头（71%）出现轻度或明显的PMWS，而9头单独感染PCV2的仔猪均未出现PMWS。12头接种含矿物油佐剂的市售菌苗的仔猪中有5头（42%）在接种后出现PMWS。在这个PCV2相关疾病模型中，其他菌苗接种组的PCV2感染仔猪均未出现PMWS。给予含矿物油佐剂的猪肺炎支原体菌苗的仔猪与其他猪肺炎支原体菌苗接种组仔猪中PMWS的患病率差异具有统计学意义（P < 0.05）。