Jolly Claire, Thoison Odile, Martin Marie-Thérèse, Dumontet Vincent, Gilbert Aline, Pfeiffer Bruno, Léonce Stéphane, Sévenet Thierry, Guéritte Françoise, Litaudon Marc
Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Phytochemistry. 2008 Jan;69(2):533-40. doi: 10.1016/j.phytochem.2007.07.015. Epub 2007 Sep 7.
In the course of an automated screening for small molecules presenting cytotoxic activity, eight new cyclophanes named kermadecins A-H (1-8), have been isolated from the bark of a New Caledonian plant, Kermadecia elliptica, Proteaceae. A LC/APCI-MS study performed on kermadecins A, B and C, provided a reliable method for the detection of other analogues existing in small quantities in the extract. This led to the isolation of five other members of this chemical series. The structures were elucidated by extensive mono- and bi-dimensional spectroscopy and mass spectrometry. The cytotoxic activity of four of them was evaluated on various cell lines.
在对具有细胞毒性活性的小分子进行自动筛选过程中，从新喀里多尼亚植物椭圆柯梅德木（山龙眼科）的树皮中分离出了8种名为柯梅德菌素A - H（1 - 8）的新型环芳烷。对柯梅德菌素A、B和C进行的液相色谱/大气压化学电离质谱研究，为检测提取物中少量存在的其他类似物提供了一种可靠方法。这使得该化学系列中的其他5个成员得以分离。通过广泛的一维和二维光谱以及质谱对其结构进行了阐明。对其中4种化合物在多种细胞系上评估了细胞毒性活性。
