通过动态O-15标记水PET成像评估心肌灌注：一种新型快速因子分析的验证
Assessment of myocardial perfusion by dynamic O-15-labeled water PET imaging: validation of a new fast factor analysis.
作者信息
Adachi Itaru, Gaemperli Oliver, Valenta Ines, Schepis Tiziano, Siegrist Patrick T, Treyer Valerie, Burger Cyrill, Morita Koichi, Kaufmann Philipp A
机构信息
Department of Medical Radiology, University Hospital Zurich, Zurich, Switzerland.
出版信息
J Nucl Cardiol. 2007 Sep-Oct;14(5):698-705. doi: 10.1016/j.nuclcard.2007.05.012.
BACKGROUND
Factor analysis (FA) is an established method for separating myocardium from blood pool by use of oxygen 15-labeled water and positron emission tomography for analyzing myocardial blood flow (MBF). Conventional FA methods generating images from sinograms (sinoFA) are time-consuming, whereas FA can be performed on the reconstructed images (reconFA) in a fraction of time. We validated the MBF values obtained by reconFA versus sinoFA.
METHODS AND RESULTS
In 23 volunteers (mean age, 26.6 +/- 3.4 years) MBF was calculated from sinoFA and reconFA and blindly reanalyzed 1 month later by the same observer. Intraobserver agreement and reconFA-versus-sinoFA agreement were assessed according to Bland and Altman (BA). Reproducibility proved excellent for global sinoFA (r = 0.968; P < .001; BA limits, -0.617 to 0.676 mL x min(-1) x g(-1)) and slightly superior for reconFA (r = 0.979; P < .001; BA limits, -0.538 to 0.558 mL x min(-1) x g(-1)), with wider limits of agreement for segmental MBF from sinoFA (r = 0.777; P < .001; BA limits, -1.676 to 1.656 mL x min(-1) x g(-1)) and reconFA (r = 0.844; P < .001; BA limits, -1.999 to 1.992 mL x min(-1) x g(-1)). In addition, sinoFA and reconFA showed excellent correlation (r = 0.975, P < .001) and agreement (BA limits, -0.528 to 0.648 mL x min(-1) x g(-1)) for global and segmental values (r = 0.955; P < .001; BA limits, -1.371 to 1.491 mL x min(-1) x g(-1)).
CONCLUSIONS
Use of reconFA allows rapid and reliable quantitative MBF assessment with O-15-labeled water.
背景
因子分析（FA）是一种通过使用氧15标记水和正电子发射断层扫描来分析心肌血流（MBF），从而将心肌与血池分离的既定方法。传统的从正弦图生成图像的因子分析方法（正弦图FA）耗时较长，而因子分析可以在重建图像上进行（重建图像FA），所需时间仅为前者的一小部分。我们验证了通过重建图像FA与正弦图FA获得的MBF值。
方法和结果
在23名志愿者（平均年龄26.6±3.4岁）中，从正弦图FA和重建图像FA计算MBF，并在1个月后由同一名观察者进行盲法重新分析。根据布兰德和奥特曼（BA）方法评估观察者内一致性以及重建图像FA与正弦图FA之间的一致性。结果表明，整体正弦图FA的再现性极佳（r = 0.968；P <.001；BA界限，-0.617至0.676 mL×min⁻¹×g⁻¹），重建图像FA略优（r = 0.979；P <.001；BA界限，-0.538至0.558 mL×min⁻¹×g⁻¹），正弦图FA的节段性MBF一致性界限更宽（r = 0.777；P <.001；BA界限，-1.676至1.656 mL×min⁻¹×g⁻¹），重建图像FA的节段性MBF一致性界限为（r = 0.844；P <.001；BA界限，-1.999至1.992 mL×min⁻¹×g⁻¹）。此外，正弦图FA和重建图像FA在整体和节段值方面显示出极佳的相关性（r = 0.975，P <.001）和一致性（BA界限，-0.528至0.648 mL×min⁻¹×g⁻¹）（r = 0.955；P <.001；BA界限，-1.371至1.491 mL×min⁻¹×g⁻¹）。
结论
使用重建图像FA能够通过氧15标记水快速且可靠地进行MBF定量评估。
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