Roelants Véronique, Bol Anne, Bernard Xavier, Coppens Ann, Melin Jacques, Gerber Bernhard, Vanoverschelde Jean-Louis
Department of Nuclear Medicine, Université Catholique de Louvain, Cliniques Universitaires St-Luc, Brussels, Belgium.
J Nucl Cardiol. 2006 Mar-Apr;13(2):220-4. doi: 10.1007/BF02971246.
Positron emission tomography scanners with retractable septa allow both 3-dimensional (3D) and 2-dimensional (2D) acquisition modes. The study aim was to directly compare 2D and 3D acquisition modes for the evaluation of absolute myocardial blood flow (MBF) over a wide range of flow values.
Instrumentation was used in 4 dogs to reduce the left circumflex artery lumen by greater than 75%. During infusion of adenosine, MBF was measured with both 2D and 3D dynamic acquisition and both oxygen 15 water and nitrogen 13 ammonia. Injected activities were 333 MBq and 111 MBq for 2D acquisition and 3D acquisition, respectively. Data were reconstructed by analytic methods, and MBF was assessed by use of an 18-segment model. MBF values ranged from 0.4 to 5.8 mL x g(-1) x min(-1) with O-15 water and from 0.3 to 3.9 mL x g(-1) x min(-1) with N-13 ammonia. No significant differences were observed in absolute MBF values obtained with the 2 acquisition modes, regardless of the flow tracer used. Two-dimensionally and three-dimensionally derived MBF values were significantly strongly correlated by use of both O-15 water (y = 0.98x + 0.18, r = 0.87, P < .001) and N-13 ammonia (y = 0.99x + 0.09, r = 0.95, P < .001).
Quantification of MBF in dogs with 3D positron emission tomography provides results similar to those obtained with the 2D technique, despite a lower activity being injected.
带有可伸缩隔板的正电子发射断层扫描仪允许三维（3D）和二维（2D）采集模式。本研究的目的是直接比较2D和3D采集模式在广泛的血流值范围内评估绝对心肌血流量（MBF）的情况。
在4只狗身上使用仪器使左旋冠状动脉管腔减少超过75%。在输注腺苷期间，使用2D和3D动态采集以及氧15水和氮13氨测量MBF。2D采集和3D采集的注射活度分别为333 MBq和111 MBq。数据通过解析方法重建，并使用18节段模型评估MBF。使用氧15水时MBF值范围为0.4至5.8 mL×g⁻¹×min⁻¹，使用氮13氨时为0.3至3.9 mL×g⁻¹×min⁻¹。无论使用何种血流示踪剂，两种采集模式获得的绝对MBF值均未观察到显著差异。使用氧15水（y = 0.98x + 0.18，r = 0.87，P <.001）和氮13氨（y = 0.99x + 0.09，r = 0.95，P <.001）时，二维和三维得出的MBF值均显著高度相关。
尽管注射的活度较低，但使用三维正电子发射断层扫描对狗的MBF进行定量分析所得到的结果与二维技术相似。
