Bounous G, Gold P
Department of Surgery, Montreal General Hospital Research Institute, Quebec.
Clin Invest Med. 1991 Aug;14(4):296-309.
This study compared the effects of different sources of whey protein concentrate (20 g/100 g diet) and of casein on the spleen, liver, and heart glutathione content of C3H/HeJ mice, and on the immune response of their spleen cells to sheep red blood cells. Body weight curves were similar in all dietary groups. Our data indicate that the humoral immune response is highest in mice fed a dietary whey protein concentrate exhibiting the highest solubility (undenatured conformation) and a greater relative concentration of the thermolabile bovine serum albumin and immunoglobulins. In addition, the mice fed this type of whey protein concentrate exhibit higher levels of tissue glutathione. The presence in the serum albumin fraction of glutamylcysteine groups (rare in food protein) and the specific intramolecular bond as related to the undenatured conformation of the molecule are considered to be key factors in the glutathione-promoting activity of the protein mixture.
本研究比较了不同来源的浓缩乳清蛋白（20克/100克日粮）和酪蛋白对C3H/HeJ小鼠脾脏、肝脏和心脏中谷胱甘肽含量的影响，以及对其脾细胞对绵羊红细胞免疫反应的影响。所有饮食组的体重曲线相似。我们的数据表明，在喂食具有最高溶解度（未变性构象）以及热不稳定牛血清白蛋白和免疫球蛋白相对浓度更高的日粮浓缩乳清蛋白的小鼠中，体液免疫反应最高。此外，喂食这种类型浓缩乳清蛋白的小鼠组织谷胱甘肽水平更高。血清白蛋白组分中谷氨酰半胱氨酸基团（在食物蛋白中罕见）的存在以及与分子未变性构象相关的特定分子内键被认为是该蛋白质混合物促进谷胱甘肽活性的关键因素。
