Bounous G, Gervais F, Amer V, Batist G, Gold P
Montreal General Hospital Research Institute, Quebec.
Clin Invest Med. 1989 Dec;12(6):343-9.
This study compared the effects of a whey-rich diet (20 g/100 g diet), with that of Purina mouse chow or casein-rich diet (20 g/100 g diet), on the liver and heart glutathione content and on the survival of old male C57BL/6NIA mice. The study was performed during a limited observation period of 6.3 months. In mice fed the whey protein-rich diet between 17 months and 20 months of age, the heart tissue and liver tissue glutathione content were enhanced significantly above the corresponding values of the casein diet-fed and Purina-fed mice. Mice fed the whey protein diet at the onset of senescence at 84 weeks, exhibited increased longevity as compared to mice fed Purina mouse chow over the 6.3 month observation period extending from the age of 21 months (corresponding to a human age of 55 years) to 26-27 months of age (corresponding to a human age of 80 years), during which time 55% mortality was observed. The corresponding mean survival time of mice fed the defined casein diet is almost identical to that of Purina-fed controls. Body weight curves were similar in all three dietary groups. Hence a whey protein diet appears to enhance the liver and heart glutathione concentration in aging mice and to increase longevity over a 6.3 month observation period.
本研究比较了富含乳清的饮食（20克/100克饮食）与普瑞纳小鼠饲料或富含酪蛋白的饮食（20克/100克饮食）对老年雄性C57BL/6NIA小鼠肝脏和心脏谷胱甘肽含量以及存活率的影响。该研究在6.3个月的有限观察期内进行。在17个月至20个月大的小鼠中，喂食富含乳清蛋白饮食的小鼠，其心脏组织和肝脏组织中的谷胱甘肽含量显著高于喂食酪蛋白饮食和普瑞纳饲料的小鼠的相应值。在84周衰老开始时喂食乳清蛋白饮食的小鼠，与在21个月龄（相当于人类55岁）至26 - 27个月龄（相当于人类80岁）的6.3个月观察期内喂食普瑞纳小鼠饲料的小鼠相比，寿命有所延长，在此期间观察到55%的死亡率。喂食特定酪蛋白饮食的小鼠的相应平均存活时间与喂食普瑞纳饲料的对照组几乎相同。所有三个饮食组的体重曲线相似。因此，在6.3个月的观察期内，乳清蛋白饮食似乎能提高衰老小鼠肝脏和心脏中的谷胱甘肽浓度并延长寿命。
