Bounous G, Papenburg R, Kongshavn P A, Gold P, Fleiszer D
Department of Surgery, Montreal General Hospital, Quebec, Canada.
Clin Invest Med. 1988 Jun;11(3):213-7.
This study investigates the influence of two formula diets containing 20 g/100 g diet of either whey protein concentrate or casein or Purina mouse chow, on the humoral immune responsiveness and dimethylhydrazine induced colon carcinogenesis in A/J mice. After 20 weeks of dimethylhydrazine treatment, the number of plaque forming cells per spleen, following intravenous inoculation with 5 X 10(6) sheep red blood cells, was nearly three times greater in the whey protein-fed group than in the casein-fed mice although both values were substantially below normal. After 24 weeks of dimethylhydrazine treatment the incidence of tumors in the whey protein-fed mice was substantially lower than that in mice fed either the casein or Purina diet. Similarly, the tumor area was less in the whey protein group in comparison to either the casein or Purina groups, with some difference between casein and Purina groups. Body weight curves were similar in all dietary groups. In conclusion, a whey protein diet appears to significantly inhibit the incidence and growth of chemically induced colon tumors in mice.
本研究调查了两种配方饮食（每100克饮食含20克乳清蛋白浓缩物或酪蛋白或普瑞纳小鼠饲料）对A/J小鼠体液免疫反应性以及二甲基肼诱导的结肠癌发生的影响。在二甲基肼处理20周后，静脉注射5×10(6)个绵羊红细胞后，每只脾脏的空斑形成细胞数量，乳清蛋白喂养组几乎是酪蛋白喂养小鼠的三倍，尽管两者的值均显著低于正常水平。在二甲基肼处理24周后，乳清蛋白喂养小鼠的肿瘤发生率显著低于酪蛋白或普瑞纳饮食喂养的小鼠。同样，与酪蛋白组或普瑞纳组相比，乳清蛋白组的肿瘤面积较小，酪蛋白组和普瑞纳组之间存在一些差异。所有饮食组的体重曲线相似。总之，乳清蛋白饮食似乎能显著抑制小鼠化学诱导的结肠肿瘤的发生率和生长。
